The gambling habits of adolescents and the relationship between gambling, other high-risk behaviors and self-esteem were investigated. One hundred eighty-five American Indian and non-Indian students in grades 7-12 in two schools (one tribal and one public) were surveyed on a Great Lakes Indian Reservation. The seventy-eight item survey replicated a previous study on another reservation. The instrument reported data by age, gender, school, ethnicity, socio-economic status, incidence of high-risk behaviors, self-esteem indicators, and incidence(s) of individual and family gambling. The results indicated statistically significant relationships between gambling habits, parental gambling, other high-risk behaviors, and self-esteem. These findings have implications for American Indian youth and their families, for tribal leaders making policy decisions, and for social workers who provide services to these communities. [Article copies available for a fee from The Haworth Document Delivery Service: 1-800-342-9678. E-mail address: email@example.com].