Adrenal Corticosteroids Cause Gastrin Cell Hyperplasia

John P. Delaney; Hector M. Michel; Margaret E. Bonsack; M. Michael Eisenberg; Daniel H. Dunn

doi:10.1016/S0016-5085(79)91317-9

Adrenal Corticosteroids Cause Gastrin Cell Hyperplasia

John P. Delaney, Hector M. Michel, Margaret E. Bonsack, M. Michael Eisenberg, Daniel H. Dunn

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Abstract

Chronic exogenous high dose adrenal cortical steroid administration to dogs resulted in a 137% increase in G-cell mass with an associated enhancement of peak serum gastrin levels. Adrenalectomy caused a halving of G-cell numbers without significant changes in serum gastrin levels. Adrenal cortical steroids appear to have an important trophic role for the G-cell.

Original language	English (US)
Pages (from-to)	913-916
Number of pages	4
Journal	Gastroenterology
Volume	76
Issue number	5
DOIs	https://doi.org/10.1016/S0016-5085(79)91317-9
State	Published - 1979

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title = "Adrenal Corticosteroids Cause Gastrin Cell Hyperplasia",

abstract = "Chronic exogenous high dose adrenal cortical steroid administration to dogs resulted in a 137% increase in G-cell mass with an associated enhancement of peak serum gastrin levels. Adrenalectomy caused a halving of G-cell numbers without significant changes in serum gastrin levels. Adrenal cortical steroids appear to have an important trophic role for the G-cell.",

author = "Delaney, {John P.} and Michel, {Hector M.} and Bonsack, {Margaret E.} and Eisenberg, {M. Michael} and Dunn, {Daniel H.}",

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T1 - Adrenal Corticosteroids Cause Gastrin Cell Hyperplasia

AU - Delaney, John P.

AU - Michel, Hector M.

AU - Bonsack, Margaret E.

AU - Eisenberg, M. Michael

AU - Dunn, Daniel H.

PY - 1979

Y1 - 1979

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AB - Chronic exogenous high dose adrenal cortical steroid administration to dogs resulted in a 137% increase in G-cell mass with an associated enhancement of peak serum gastrin levels. Adrenalectomy caused a halving of G-cell numbers without significant changes in serum gastrin levels. Adrenal cortical steroids appear to have an important trophic role for the G-cell.

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Adrenal Corticosteroids Cause Gastrin Cell Hyperplasia

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