Advancement in bioprocess technology: parallels between microbial natural products and cell culture biologics

Arpan A. Bandyopadhyay; Anurag Khetan; Li Hong Malmberg; Weichang Zhou; Wei Shou Hu

doi:10.1007/s10295-017-1913-4

Advancement in bioprocess technology: parallels between microbial natural products and cell culture biologics

Arpan A. Bandyopadhyay, Anurag Khetan, Li Hong Malmberg, Weichang Zhou, Wei Shou Hu

Chemical Engineering and Materials Science

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

The emergence of natural products and industrial microbiology nearly eight decades ago propelled an era of bioprocess innovation. Half a century later, recombinant protein technology spurred the tremendous growth of biologics and added mammalian cells to the forefront of industrial producing cells in terms of the value of products generated. This review highlights the process technology of natural products and protein biologics. Despite the separation in time, there is a remarkable similarity in their progression. As the new generation of therapeutics for gene and cell therapy emerges, its process technology development can take inspiration from that of natural products and biologics.

Original language	English (US)
Pages (from-to)	785-797
Number of pages	13
Journal	Journal of Industrial Microbiology and Biotechnology
Volume	44
Issue number	4-5
DOIs	https://doi.org/10.1007/s10295-017-1913-4
State	Published - May 1 2017

Bibliographical note

Publisher Copyright:
© 2017, Society for Industrial Microbiology and Biotechnology.

Keywords

Natural products
Process technology
Protein biologics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Advancement in bioprocess technology: parallels between microbial natural products and cell culture biologics

Abstract

Bibliographical note

Keywords

UN SDGs

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