Advances in standardization of laboratory measurement procedures: Implications for measuring biomarkers of folate and vitamin B-12 status in NHANES

Jay L. Bock, John H. Eckfeldt

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Population studies such as NHANES analyze large numbers of laboratory measurements and are often performed in different laboratories using different measurement procedures and over an extended period of time. Correct clinical and epidemiologic interpretations of the results depend on the accuracy of those measurements. Unfortunately, considerable variability has been observed among assays for folate, vitamin B-12, and related biomarkers. In the past few decades, the science of metrology has advanced considerably, with the development of improved primary reference measurement procedures and high-level reference materials, which can serve as the basis for accurate measurement. A rigorous approach has been established for making field methods traceable to the highest-level reference measurement procedures and reference materials. This article reviews some basic principles of metrology and describes their recent application to measurements of folate and vitamin B-12.

Original languageEnglish (US)
Pages (from-to)332S-336S
JournalAmerican Journal of Clinical Nutrition
Volume94
Issue number1
DOIs
StatePublished - Jul 1 2011

Fingerprint

Dive into the research topics of 'Advances in standardization of laboratory measurement procedures: Implications for measuring biomarkers of folate and vitamin B-12 status in NHANES'. Together they form a unique fingerprint.

Cite this