Advances in the analysis of single mitochondria

Kathryn M. Fuller; Edgar A. Arriaga

doi:10.1016/S0958-1669(02)00008-3

Advances in the analysis of single mitochondria

Kathryn M. Fuller, Edgar A. Arriaga

Chemistry (Twin Cities)

Research output: Contribution to journal › Review article › peer-review

42 Scopus citations

Abstract

Mitochondria are both morphologically and functionally diverse, and this variety is thought to have important biological ramifications. The development of methods to probe the properties of individual mitochondria is therefore of utmost importance. Recent advances have been made using in situ microscopy techniques and methods to investigate isolated mitochondria, including flow cytometry, capillary electrophoresis, patch-clamping and optical trapping. Such techniques have been used to study metabolism, mitochondrial calcium homeostasis, mitochondrial membrane potential, apoptosis, and other properties.

Original language	English (US)
Pages (from-to)	35-41
Number of pages	7
Journal	Current opinion in biotechnology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/S0958-1669(02)00008-3
State	Published - Feb 2003

Bibliographical note

Funding Information:
KMF acknowledges initial support from a National Institute of Health Chemistry/Biology Interface Training Grant (Grant GM08700). EAA is supported by the National Institute of Health (Grants R01 GM61969 and RO1 AG20866).

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Advances in the analysis of single mitochondria

Abstract

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