Advances in understanding and treating dystrophic epidermolysis bullosa

Michael J. Vanden Oever, Jakub Tolar

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Epidermolysis bullosa is a group of inherited disorders that can be both systemic and life-threatening. Standard treatments for the most severe forms of this disorder, typically limited to palliative care, are ineffective in reducing the morbidity and mortality due to complications of the disease. Emerging therapies - such as the use of allogeneic cellular therapy, gene therapy, and protein therapy - have all shown promise, but it is likely that several approaches will need to be combined to realize a cure. For recessive dystrophic epidermolysis bullosa, each particular therapeutic approach has added to our understanding of type VII collagen (C7) function and the basic biology surrounding the disease. The efficacy of these therapies and the mechanisms by which they function also give us insight into developing future strategies for treating this and other extracellular matrix disorders.

Original languageEnglish (US)
Article number35
JournalF1000Prime Reports
Volume6
DOIs
StatePublished - May 6 2014

Fingerprint

Dive into the research topics of 'Advances in understanding and treating dystrophic epidermolysis bullosa'. Together they form a unique fingerprint.

Cite this