Advancing directional deep brain stimulation array technology

Julia P. Slopsema, Robert Cass, Mark Hjelle, Matthew D. Johnson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The degree to which deep brain stimulation (DBS) therapy can effectively treat various brain disorders depends on how well one can selectively stimulate one or more axonal pathways within the brain. There is rapidly growing clinical interest in DBS lead implant designs with electrode arrangements that can better target axonal pathways of interest, especially in cases where the optimal target is immediately adjacent to a pathway that when stimulated will elicit adverse side effects. Numerical modeling has demonstrated that DBS leads with four radially segmented electrodes provide the best balance of directional targeting capability while minimizing the overall number of electrode contacts [1]. Here, we present a novel 4x4 DBS lead (16-channel electrode array) with the same form factor and materials as current 4 or 8-channel FDA-approved DBS leads. Electrode impedance spectroscopy was performed for three of these 4x4 DBS leads showing reliable electrode impedances before and after implantation within the brain.

Original languageEnglish (US)
Title of host publicationFrontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019
PublisherAmerican Society of Mechanical Engineers (ASME)
ISBN (Electronic)9780791841037
DOIs
StatePublished - 2019
Event2019 Design of Medical Devices Conference, DMD 2019 - Minneapolis, United States
Duration: Apr 15 2019Apr 18 2019

Publication series

NameFrontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019

Conference

Conference2019 Design of Medical Devices Conference, DMD 2019
CountryUnited States
CityMinneapolis
Period4/15/194/18/19

Bibliographical note

Funding Information:
We thank the engineering and fabrication teams at Heraeus Medical Components. We also thank AnneMarie Brinda and Michelle Uchenik for assistance with impedance spectroscopy measurements. This study was funded in part by the NIH under grants R01-NS094206 and P50-NS098573. JPS was funded by the NSF Graduate Research Fellowship Program (NSF-GRFP, 00039202).

Publisher Copyright:
Copyright © 2019 ASME

Keywords

  • Dbs
  • Deep brain stimulation
  • Directional
  • Electrode array
  • Platinum

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