Advancing directional deep brain stimulation array technology

Julia P. Slopsema; Robert Cass; Mark Hjelle; Matthew D. Johnson

doi:10.1115/DMD2019-3312

Advancing directional deep brain stimulation array technology

Julia P. Slopsema, Robert Cass, Mark Hjelle, Matthew D. Johnson

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

The degree to which deep brain stimulation (DBS) therapy can effectively treat various brain disorders depends on how well one can selectively stimulate one or more axonal pathways within the brain. There is rapidly growing clinical interest in DBS lead implant designs with electrode arrangements that can better target axonal pathways of interest, especially in cases where the optimal target is immediately adjacent to a pathway that when stimulated will elicit adverse side effects. Numerical modeling has demonstrated that DBS leads with four radially segmented electrodes provide the best balance of directional targeting capability while minimizing the overall number of electrode contacts [1]. Here, we present a novel 4x4 DBS lead (16-channel electrode array) with the same form factor and materials as current 4 or 8-channel FDA-approved DBS leads. Electrode impedance spectroscopy was performed for three of these 4x4 DBS leads showing reliable electrode impedances before and after implantation within the brain.

Original language	English (US)
Title of host publication	Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019
Publisher	American Society of Mechanical Engineers (ASME)
ISBN (Electronic)	9780791841037
DOIs	https://doi.org/10.1115/DMD2019-3312
State	Published - 2019
Event	2019 Design of Medical Devices Conference, DMD 2019 - Minneapolis, United States Duration: Apr 15 2019 → Apr 18 2019

Publication series

Name	Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019

Conference

Conference	2019 Design of Medical Devices Conference, DMD 2019
Country/Territory	United States
City	Minneapolis
Period	4/15/19 → 4/18/19

Bibliographical note

Funding Information:
We thank the engineering and fabrication teams at Heraeus Medical Components. We also thank AnneMarie Brinda and Michelle Uchenik for assistance with impedance spectroscopy measurements. This study was funded in part by the NIH under grants R01-NS094206 and P50-NS098573. JPS was funded by the NSF Graduate Research Fellowship Program (NSF-GRFP, 00039202).

Publisher Copyright:
Copyright © 2019 ASME

Keywords

Dbs
Deep brain stimulation
Directional
Electrode array
Platinum

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10.1115/DMD2019-3312

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Slopsema, J. P., Cass, R., Hjelle, M., & Johnson, M. D. (2019). Advancing directional deep brain stimulation array technology. In Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019 (Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/DMD2019-3312

Advancing directional deep brain stimulation array technology. / Slopsema, Julia P.; Cass, Robert; Hjelle, Mark et al.
Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019. American Society of Mechanical Engineers (ASME), 2019. (Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Slopsema, JP, Cass, R, Hjelle, M & Johnson, MD 2019, Advancing directional deep brain stimulation array technology. in Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019. Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019, American Society of Mechanical Engineers (ASME), 2019 Design of Medical Devices Conference, DMD 2019, Minneapolis, United States, 4/15/19. https://doi.org/10.1115/DMD2019-3312

Slopsema JP, Cass R, Hjelle M, Johnson MD. Advancing directional deep brain stimulation array technology. In Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019. American Society of Mechanical Engineers (ASME). 2019. (Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019). doi: 10.1115/DMD2019-3312

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Advancing directional deep brain stimulation array technology

Abstract

Publication series

Conference

Bibliographical note

Keywords

Access

OpenUrl availability

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