Aerosol transmission of chronic wasting disease in white-tailed deer

Nathaniel D. Denkers; Jeanette Hayes-Klug; Kelly R. Anderson; Davis M. Seelig; Nicholas J. Haley; Sallie J. Dahmes; David A. Osborn; Karl V. Miller; R. J. Warren; Candace K. Mathiason; Edward A. Hoover

doi:10.1128/JVI.02852-12

Aerosol transmission of chronic wasting disease in white-tailed deer

Nathaniel D. Denkers, Jeanette Hayes-Klug, Kelly R. Anderson, Davis M. Seelig, Nicholas J. Haley, Sallie J. Dahmes, David A. Osborn, Karl V. Miller, R. J. Warren, Candace K. Mathiason, Edward A. Hoover

Veterinary Clinical Sciences

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

While the facile transmission of chronic wasting disease (CWD) remains incompletely elucidated, studies in rodents suggest that exposure of the respiratory mucosa may be an efficient pathway. The present study was designed to address this question in the native cervid host. Here, we demonstrate aerosol transmission of CWD to deer with a prion dose>20-fold lower than that used in previous oral inoculations. Inhalation of prions may facilitate transmission of CWD and, perhaps, other prion infections.

Original language	English (US)
Pages (from-to)	1890-1892
Number of pages	3
Journal	Journal of virology
Volume	87
Issue number	3
DOIs	https://doi.org/10.1128/JVI.02852-12
State	Published - Feb 2013

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title = "Aerosol transmission of chronic wasting disease in white-tailed deer",

abstract = "While the facile transmission of chronic wasting disease (CWD) remains incompletely elucidated, studies in rodents suggest that exposure of the respiratory mucosa may be an efficient pathway. The present study was designed to address this question in the native cervid host. Here, we demonstrate aerosol transmission of CWD to deer with a prion dose>20-fold lower than that used in previous oral inoculations. Inhalation of prions may facilitate transmission of CWD and, perhaps, other prion infections.",

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AU - Denkers, Nathaniel D.

AU - Hayes-Klug, Jeanette

AU - Anderson, Kelly R.

AU - Seelig, Davis M.

AU - Haley, Nicholas J.

AU - Dahmes, Sallie J.

AU - Osborn, David A.

AU - Miller, Karl V.

AU - Warren, R. J.

AU - Mathiason, Candace K.

AU - Hoover, Edward A.

PY - 2013/2

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Aerosol transmission of chronic wasting disease in white-tailed deer

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