Age-related heterogeneity in dental caries and associated risk factors in individuals with cystic fibrosis ages 6–20 years: A pilot study

Donald L. Chi; Margaret Rosenfeld; Lloyd Mancl; Whasun O. Chung; Richard B. Presland; Elise Sarvas; Marilynn Rothen; Alaa Alkhateeb; Sharon McNamara; Alan Genatossio; Isabel Virella-Lowell; Carlos Milla; Jo Anna Scott

doi:10.1016/j.jcf.2018.06.009

Age-related heterogeneity in dental caries and associated risk factors in individuals with cystic fibrosis ages 6–20 years: A pilot study

Donald L. Chi, Margaret Rosenfeld, Lloyd Mancl, Whasun O. Chung, Richard B. Presland, Elise Sarvas, Marilynn Rothen, Alaa Alkhateeb, Sharon McNamara, Alan Genatossio, Isabel Virella-Lowell, Carlos Milla, Jo Anna Scott

Developmental and Surgical Sciences

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Abstract

Background: The literature conflicts regarding dental caries risk in cystic fibrosis (CF) relative to controls. Methods: Prospective, observational study of age-related heterogeneity in caries rates and potential risk factors in individuals with CF ages 6-20 at a single clinic in Washington state (N=85). Caries rates for enrolled CF participants and historical controls from NHANES were compared using cubic spline regression models. Generalized linear regression models identified correlates of age and caries in CF. Results: Children ages 6-9 with CF had significantly lower caries than controls (Holm's P<0.05). There was no difference for ages 10-20 by CF status (Holm's P>0.05). Various biological/intraoral, medical, and behavioral factors were associated with caries and age in CF. Conclusions: Younger children with CF may be protected from caries, but there is apparent loss of protection in early adolescence associated with multiple risk factors. Additional studies are needed to confirm these findings.

Original language	English (US)
Pages (from-to)	747-759
Number of pages	13
Journal	Journal of Cystic Fibrosis
Volume	17
Issue number	6
DOIs	https://doi.org/10.1016/j.jcf.2018.06.009
State	Published - Nov 2018

Bibliographical note

Funding Information:
This work was supported, in part, by grant funding and support from the Sunstar Americas Pediatric Prevention Award, the University of Washington, Cystic Fibrosis Foundation Research Development Program, the U.S. National Institute of Dental and Craniofacial Research [grant numbers K08DE020856 and T90DE021984], the U.S. National Institute of Health National Center for Advancing Translational Sciences, Clinical and Translational Science Award (CTSA) [grant number UL1TR002319], King Saud University, the William T. Grant Foundation Scholars Program, and the Center for Advanced Study in the Behavioral Sciences (CASBS) at Stanford University.

Funding Information:
This work was supported, in part, by grant funding and support from the Sunstar Americas Pediatric Prevention Award , the University of Washington , Cystic Fibrosis Foundation Research Development Program , the U.S. National Institute of Dental and Craniofacial Research [grant numbers K08DE020856 and T90DE021984 ], the U.S. National Institute of Health National Center for Advancing Translational Sciences , Clinical and Translational Science Award (CTSA) [grant number UL1TR002319 ], King Saud University , the William T. Grant Foundation Scholars Program , and the Center for Advanced Study in the Behavioral Sciences (CASBS) at Stanford University .

Publisher Copyright:
© 2018 European Cystic Fibrosis Society

Keywords

Caries risk factors
Cystic fibrosis
Dental caries
Pediatric dentistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jcf.2018.06.009

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589399

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Chi, D. L., Rosenfeld, M., Mancl, L., Chung, W. O., Presland, R. B., Sarvas, E., Rothen, M., Alkhateeb, A., McNamara, S., Genatossio, A., Virella-Lowell, I., Milla, C., & Scott, J. A. (2018). Age-related heterogeneity in dental caries and associated risk factors in individuals with cystic fibrosis ages 6–20 years: A pilot study. Journal of Cystic Fibrosis, 17(6), 747-759. https://doi.org/10.1016/j.jcf.2018.06.009

Chi, DL, Rosenfeld, M, Mancl, L, Chung, WO, Presland, RB, Sarvas, E, Rothen, M, Alkhateeb, A, McNamara, S, Genatossio, A, Virella-Lowell, I, Milla, C & Scott, JA 2018, 'Age-related heterogeneity in dental caries and associated risk factors in individuals with cystic fibrosis ages 6–20 years: A pilot study', Journal of Cystic Fibrosis, vol. 17, no. 6, pp. 747-759. https://doi.org/10.1016/j.jcf.2018.06.009

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abstract = "Background: The literature conflicts regarding dental caries risk in cystic fibrosis (CF) relative to controls. Methods: Prospective, observational study of age-related heterogeneity in caries rates and potential risk factors in individuals with CF ages 6-20 at a single clinic in Washington state (N=85). Caries rates for enrolled CF participants and historical controls from NHANES were compared using cubic spline regression models. Generalized linear regression models identified correlates of age and caries in CF. Results: Children ages 6-9 with CF had significantly lower caries than controls (Holm's P<0.05). There was no difference for ages 10-20 by CF status (Holm's P>0.05). Various biological/intraoral, medical, and behavioral factors were associated with caries and age in CF. Conclusions: Younger children with CF may be protected from caries, but there is apparent loss of protection in early adolescence associated with multiple risk factors. Additional studies are needed to confirm these findings.",

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author = "Chi, {Donald L.} and Margaret Rosenfeld and Lloyd Mancl and Chung, {Whasun O.} and Presland, {Richard B.} and Elise Sarvas and Marilynn Rothen and Alaa Alkhateeb and Sharon McNamara and Alan Genatossio and Isabel Virella-Lowell and Carlos Milla and Scott, {Jo Anna}",

note = "Funding Information: This work was supported, in part, by grant funding and support from the Sunstar Americas Pediatric Prevention Award, the University of Washington, Cystic Fibrosis Foundation Research Development Program, the U.S. National Institute of Dental and Craniofacial Research [grant numbers K08DE020856 and T90DE021984], the U.S. National Institute of Health National Center for Advancing Translational Sciences, Clinical and Translational Science Award (CTSA) [grant number UL1TR002319], King Saud University, the William T. Grant Foundation Scholars Program, and the Center for Advanced Study in the Behavioral Sciences (CASBS) at Stanford University. Funding Information: This work was supported, in part, by grant funding and support from the Sunstar Americas Pediatric Prevention Award , the University of Washington , Cystic Fibrosis Foundation Research Development Program , the U.S. National Institute of Dental and Craniofacial Research [grant numbers K08DE020856 and T90DE021984 ], the U.S. National Institute of Health National Center for Advancing Translational Sciences , Clinical and Translational Science Award (CTSA) [grant number UL1TR002319 ], King Saud University , the William T. Grant Foundation Scholars Program , and the Center for Advanced Study in the Behavioral Sciences (CASBS) at Stanford University . Publisher Copyright: {\textcopyright} 2018 European Cystic Fibrosis Society",

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T2 - A pilot study

AU - Chi, Donald L.

AU - Rosenfeld, Margaret

AU - Mancl, Lloyd

AU - Chung, Whasun O.

AU - Presland, Richard B.

AU - Sarvas, Elise

AU - Rothen, Marilynn

AU - Alkhateeb, Alaa

AU - McNamara, Sharon

AU - Genatossio, Alan

AU - Virella-Lowell, Isabel

AU - Milla, Carlos

AU - Scott, Jo Anna

N1 - Funding Information: This work was supported, in part, by grant funding and support from the Sunstar Americas Pediatric Prevention Award, the University of Washington, Cystic Fibrosis Foundation Research Development Program, the U.S. National Institute of Dental and Craniofacial Research [grant numbers K08DE020856 and T90DE021984], the U.S. National Institute of Health National Center for Advancing Translational Sciences, Clinical and Translational Science Award (CTSA) [grant number UL1TR002319], King Saud University, the William T. Grant Foundation Scholars Program, and the Center for Advanced Study in the Behavioral Sciences (CASBS) at Stanford University. Funding Information: This work was supported, in part, by grant funding and support from the Sunstar Americas Pediatric Prevention Award , the University of Washington , Cystic Fibrosis Foundation Research Development Program , the U.S. National Institute of Dental and Craniofacial Research [grant numbers K08DE020856 and T90DE021984 ], the U.S. National Institute of Health National Center for Advancing Translational Sciences , Clinical and Translational Science Award (CTSA) [grant number UL1TR002319 ], King Saud University , the William T. Grant Foundation Scholars Program , and the Center for Advanced Study in the Behavioral Sciences (CASBS) at Stanford University . Publisher Copyright: © 2018 European Cystic Fibrosis Society

PY - 2018/11

Y1 - 2018/11

N2 - Background: The literature conflicts regarding dental caries risk in cystic fibrosis (CF) relative to controls. Methods: Prospective, observational study of age-related heterogeneity in caries rates and potential risk factors in individuals with CF ages 6-20 at a single clinic in Washington state (N=85). Caries rates for enrolled CF participants and historical controls from NHANES were compared using cubic spline regression models. Generalized linear regression models identified correlates of age and caries in CF. Results: Children ages 6-9 with CF had significantly lower caries than controls (Holm's P<0.05). There was no difference for ages 10-20 by CF status (Holm's P>0.05). Various biological/intraoral, medical, and behavioral factors were associated with caries and age in CF. Conclusions: Younger children with CF may be protected from caries, but there is apparent loss of protection in early adolescence associated with multiple risk factors. Additional studies are needed to confirm these findings.

AB - Background: The literature conflicts regarding dental caries risk in cystic fibrosis (CF) relative to controls. Methods: Prospective, observational study of age-related heterogeneity in caries rates and potential risk factors in individuals with CF ages 6-20 at a single clinic in Washington state (N=85). Caries rates for enrolled CF participants and historical controls from NHANES were compared using cubic spline regression models. Generalized linear regression models identified correlates of age and caries in CF. Results: Children ages 6-9 with CF had significantly lower caries than controls (Holm's P<0.05). There was no difference for ages 10-20 by CF status (Holm's P>0.05). Various biological/intraoral, medical, and behavioral factors were associated with caries and age in CF. Conclusions: Younger children with CF may be protected from caries, but there is apparent loss of protection in early adolescence associated with multiple risk factors. Additional studies are needed to confirm these findings.

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Age-related heterogeneity in dental caries and associated risk factors in individuals with cystic fibrosis ages 6–20 years: A pilot study

Abstract

Bibliographical note

Keywords

UN SDGs

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