Aggregated Solution Morphology of Poly(acrylic acid)-Poly(styrene) Block Copolymers Improves Drug Supersaturation Maintenance and Caco-2 Cell Membrane Permeation

Medicine & Life Sciences

• styrofoam 100%
• carbopol 940 91%
• Caco-2 Cells 72%
• Cell Membrane 45%
• Maintenance 43%
• Probucol 32%
• Pharmaceutical Preparations 25%
• Polymers 15%
• poly(styrene-b-acrylic acid) 10%
• Excipients 10%
• Solubility 8%
• Small Intestine 8%
• Biological Availability 7%
• Membranes 7%
• Biopharmaceutics 6%
• Stomach 6%
• Polystyrenes 5%
• X-Ray Diffraction 5%
• Nanostructures 5%
• Polymerization 4%
• Powders 4%
• Biological Products 4%
• Electron Scanning Microscopy 4%
• Permeability 3%
• Molecular Weight 3%
• Water 2%
• In Vitro Techniques 1%

Chemical Compounds

• Supersaturation 71%
• Acrylic Acid 55%
• Block Copolymer 49%
• Styrene 49%
• Probucol 45%
• Drug 32%
• Excipient 12%
• Bioavailability 10%
• pH Value 9%
• Dissolution 8%
• Amorphous Material 7%
• Block Like Crystal 7%
• Solubility 7%
• Diblock Copolymer 5%
• Solubilization 5%
• Single Monomer Polymer 5%
• Spray 5%
• Permeability 4%
• Water Soluble 4%
• Powder X-Ray Diffraction 4%
• Pharmaceutical 4%
• Nanomaterial 3%
• Polymerization Reaction 3%
• Scanning Electron Microscopy 3%
• Environment 3%
• Weight 2%
• Amount 2%