Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor

Medicine & Life Sciences

• Agouti-Related Protein 100%
• Receptor, Melanocortin, Type 4 92%
• Brain 30%
• Melanocortins 30%
• 4-Nle-7-Phe-alpha-mSH 20%
• Feeding Behavior 20%
• arginyl-tryptophyl-N-methylphenylalanyl-tryptophyl-leucyl-methioninamide 19%
• SHU 9119 18%
• Receptor, Melanocortin, Type 3 17%
• Melanocortin Receptors 16%
• Homeostasis 15%
• Melanocyte-Stimulating Hormones 15%
• G-Protein-Coupled Receptors 10%
• Hypothalamus 9%
• Transgenic Mice 9%
• Eating 7%
• Body Weight 7%
• Peptides 6%
• Phenotype 6%
• In Vitro Techniques 4%

Chemical Compounds

• Inverse Agonist 88%
• Melanocortin Receptor Agonist 19%
• Antagonist 19%
• Melanocortin 16%
• Energy 9%
• Food 7%
• Peptide 6%
• Weight 5%