TY - JOUR
T1 - Alcohol, fish, fibre and antioxidant vitamins intake do not explain population differences in coronary heart disease mortality
AU - Kromhout, Daan
AU - Bloemberg, Bennie P.M.
AU - Feskens, Edith J.M.
AU - Hertog, Michael G.L.
AU - Menotti, Alessandro
AU - Blackburn, Henry
N1 - Funding Information:
The mortality follow-up in Dalmatia and Slavonia was supported by a grant from the Netherlands Nutrition Foundation.
PY - 1996/8
Y1 - 1996/8
N2 - Background. Within the Seven Countries Study data we investigated whether population differences in 25-year mortality rates from coronary heart disease could be explained by population differences in alcohol, fish, fibre and antioxidant intake. Methods. Baseline surveys were carried out between 1958 and 1964, on 12,763 middle-aged men constituting 16 cohorts in seven countries. In 1987 and 1988 equivalent food composites representing the average food intake of each cohort at baseline were collected locally and analysed for their fibre and antioxidant content in one central laboratory. The vital status of all participants was verified at regular intervals over 25 years. Results. Alcohol and fish intake were inversely related to 25-year mortality from coronary heart disease in univariate analyses. These associations became non-significant when the confounding effects of saturated fatty acids, flavonoids and smoking were taken into account. Fibre and antioxidant vitamins intake were not related to coronary heart disease mortality in either uni- or multivariate analysis. Conclusion. These cross-cultural analyses show that alcohol, fish, fibre and antioxidant vitamins do not explain population differences in coronary heart disease mortality, independently of saturated fatty acids and flavonoids intake and cigarette smoking.
AB - Background. Within the Seven Countries Study data we investigated whether population differences in 25-year mortality rates from coronary heart disease could be explained by population differences in alcohol, fish, fibre and antioxidant intake. Methods. Baseline surveys were carried out between 1958 and 1964, on 12,763 middle-aged men constituting 16 cohorts in seven countries. In 1987 and 1988 equivalent food composites representing the average food intake of each cohort at baseline were collected locally and analysed for their fibre and antioxidant content in one central laboratory. The vital status of all participants was verified at regular intervals over 25 years. Results. Alcohol and fish intake were inversely related to 25-year mortality from coronary heart disease in univariate analyses. These associations became non-significant when the confounding effects of saturated fatty acids, flavonoids and smoking were taken into account. Fibre and antioxidant vitamins intake were not related to coronary heart disease mortality in either uni- or multivariate analysis. Conclusion. These cross-cultural analyses show that alcohol, fish, fibre and antioxidant vitamins do not explain population differences in coronary heart disease mortality, independently of saturated fatty acids and flavonoids intake and cigarette smoking.
KW - Alcohol
KW - Antioxidants
KW - Coronary heart disease
KW - Fibre
KW - Fish
KW - Vitamins
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U2 - 10.1093/ije/25.4.753
DO - 10.1093/ije/25.4.753
M3 - Article
C2 - 8921452
AN - SCOPUS:0029738769
SN - 0300-5771
VL - 25
SP - 753
EP - 759
JO - International journal of epidemiology
JF - International journal of epidemiology
IS - 4
ER -