TY - JOUR
T1 - Alkylating agents in bronchogenic carcinoma
AU - Green, Robert A.
AU - Humphrey, Edward
AU - Close, Henry
AU - Patno, Mary Ellen
PY - 1969/4
Y1 - 1969/4
N2 - A large number of patients in a group of Veterans Administration Hospitals received a variety of alkylating agents in studies in which these agents were randomized with an inert compound. Intravenous cyclophosphamide, and possibly nitrogen mustard, had a slight favorable influence upon survival for all patients. A difference between the two agents was seen: patients with squamous cell carcinoma appeared to respond best to nitrogen mustard therapy and patients with small cell undifferentiated carcinoma to cyclophosphamide therapy, in fairly striking fashion. Over-all influences upon survival, however, were not remarkable.
AB - A large number of patients in a group of Veterans Administration Hospitals received a variety of alkylating agents in studies in which these agents were randomized with an inert compound. Intravenous cyclophosphamide, and possibly nitrogen mustard, had a slight favorable influence upon survival for all patients. A difference between the two agents was seen: patients with squamous cell carcinoma appeared to respond best to nitrogen mustard therapy and patients with small cell undifferentiated carcinoma to cyclophosphamide therapy, in fairly striking fashion. Over-all influences upon survival, however, were not remarkable.
UR - http://www.scopus.com/inward/record.url?scp=0014498661&partnerID=8YFLogxK
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U2 - 10.1016/0002-9343(69)90071-0
DO - 10.1016/0002-9343(69)90071-0
M3 - Article
C2 - 5791000
AN - SCOPUS:0014498661
SN - 0002-9343
VL - 46
SP - 516
EP - 525
JO - The American Journal of Medicine
JF - The American Journal of Medicine
IS - 4
ER -
