Allosteric interaction of dynorphin and myelin basic protein with muscarinic receptors

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Abstract

Interaction of the basic peptides dynorphin A and myelin basic protein with muscarinic receptors was investigated in rat heart and cerebral cortex using radioligand receptor binding assays. Results showed that these peptides inhibit the binding of the muscarinic ligand [3H]N-methylscopolamine at equilibrium and alter the kinetics of ligand dissociation in an allosteric fashion. The number of basic amino acid residues in the composition of dynorphin A is important in eliciting its allosteric interactions. Our data suggest that endogenous basic peptides play a role in regulating the conformation of muscarinic receptors.

Original languageEnglish (US)
Pages (from-to)351-359
Number of pages9
JournalPharmacology
Volume47
Issue number6
DOIs
StatePublished - Jan 1 1993

Keywords

  • Allosteric interaction
  • Dynorphin
  • Muscarinic receptor
  • Myelin basic protein
  • Rat cerebral cortex
  • Rat heart
  • [H]N-methylscopolamine

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