Alpha-1-adrenergic receptors: Targets for agonist drugs to treat heart failure

Brian C. Jensen, Timothy D. O'Connell, Paul C. Simpson

Research output: Contribution to journalReview articlepeer-review

81 Scopus citations

Abstract

Evidence from cell, animal, and human studies demonstrates that α1-adrenergic receptors mediate adaptive and protective effects in the heart. These effects may be particularly important in chronic heart failure, when catecholamine levels are elevated and β-adrenergic receptors are down-regulated and dysfunctional. This review summarizes these data and proposes that selectively activating α1-adrenergic receptors in the heart might represent a novel and effective way to treat heart failure. This article is part of a special issue entitled "Key Signaling Molecules in Hypertrophy and Heart Failure".

Original languageEnglish (US)
Pages (from-to)518-528
Number of pages11
JournalJournal of Molecular and Cellular Cardiology
Volume51
Issue number4
DOIs
StatePublished - Oct 2011
Externally publishedYes

Bibliographical note

Funding Information:
We thank the NIH (B.C.J., T.D.O., P.C.S.); the Department of Veterans Affairs Research Service (P.C.S.); the GlaxoSmithKline Research and Education Foundation for Cardiovascular Disease (B.C.J.); the University of California, San Francisco, Foundation for Cardiac Research (B.C.J.); the American Heart Association, Western States Affiliate (P.C.S.); and the American Heart Association, Greater Midwest Affiliate (T.D.O.).

Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.

Keywords

  • Alpha-1-Adrenergic receptors
  • Cardiac myocytes
  • Drug development
  • Heart failure

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