Altered allergen binding capacities of Amb a 1-specific IgE and IgG4 from ragweed-sensitive patients receiving immunotherapy

Lisa K. Pierson-Mullany, Duaine Jackola, Malcolm N Blumenthal, Andreas Rosenberg

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Background: The mechanisms for the effectiveness of allergen immunotherapy (IT) are not well understood. The binding potential for immunoglobulins is a function of both antibody concentration and affinity (K(A)). Purpose: The purpose was to perform a cross-sectional preliminary study to investigate any differences in allergen-specific antibody affinity and concentration following ragweed immunotherapy by introducing a new concept of antibody binding capacity ([Ig] x K(A)). Methods: The binding capacity of allergen-specific IgE and IgG4 was determined for ragweed- allergic individuals undergoing ragweed immunotherapy and compared with the capacity of ragweed-specific IgE and IgG4 for allergic individuals not receiving immunotherapy. Results: The mean binding capacity for IgG4 after long-term immunotherapy was 1.6 log units higher (P < .0001) than for individuals not receiving IT. The binding capacity for allergen-specific IgE was 1.2 log units lower following long-term immunotherapy (P < .0001) compared with individuals not receiving ragweed IT. Conclusions: We hypothesize that a primary effect of immunotherapy is to increase IgG4 binding capacity and concomitantly decrease IgE binding capacity.

Original languageEnglish (US)
Pages (from-to)241-243
Number of pages3
JournalAnnals of Allergy, Asthma and Immunology
Volume84
Issue number2
DOIs
StatePublished - Feb 2000

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