TY - JOUR
T1 - Alternaria alternata soft tissue infection in a forearm transplant recipient
AU - Bonatti, Hugo
AU - Lass-Flörl, Cornelia
AU - Zelger, Bettina
AU - Lottersberger, Clemens
AU - Singh, Nina
AU - Pruett, Timothy L.
AU - Margreiter, Raimund
AU - Schneeberger, Stefan
PY - 2007/10/1
Y1 - 2007/10/1
N2 - Background: Composite tissue allograft recipients require intensive immunosuppression and are therefore at risk of infections. Filamentous fungal infections are among the complications most difficult to manage in organ transplant recipients. Methods: Case report and literature review. Case Report: Two years after bilateral forearm transplantation, a 35-year-old patient presented with a tumor-like lesion on his thigh after a penetrating injury caused by a sliver acquired during hiking. The lesion was excised completely, and microscopic examination revealed a filamentous fungal infection. Alternaria alternata was identified as the causative agent. Induction therapy with liposomal amphotericin B for one week followed by oral itraconazole maintenance therapy for eight weeks was successful, with no signs of recurrence or side effects at 18 months' follow-up. Conclusion: This is the first reported case of invasive A. alternata infection in a composite tissue allograft recipient. The infection was managed successfully with local excision and systemic antifungal treatment.
AB - Background: Composite tissue allograft recipients require intensive immunosuppression and are therefore at risk of infections. Filamentous fungal infections are among the complications most difficult to manage in organ transplant recipients. Methods: Case report and literature review. Case Report: Two years after bilateral forearm transplantation, a 35-year-old patient presented with a tumor-like lesion on his thigh after a penetrating injury caused by a sliver acquired during hiking. The lesion was excised completely, and microscopic examination revealed a filamentous fungal infection. Alternaria alternata was identified as the causative agent. Induction therapy with liposomal amphotericin B for one week followed by oral itraconazole maintenance therapy for eight weeks was successful, with no signs of recurrence or side effects at 18 months' follow-up. Conclusion: This is the first reported case of invasive A. alternata infection in a composite tissue allograft recipient. The infection was managed successfully with local excision and systemic antifungal treatment.
UR - http://www.scopus.com/inward/record.url?scp=36148951010&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36148951010&partnerID=8YFLogxK
U2 - 10.1089/sur.2006.095
DO - 10.1089/sur.2006.095
M3 - Article
C2 - 17999589
AN - SCOPUS:36148951010
SN - 1096-2964
VL - 8
SP - 539
EP - 544
JO - Surgical infections
JF - Surgical infections
IS - 5
ER -