The lithium enolate derived from benzamidoacetone (1) can be regiospecifically alkylated at C(1) and stereospecifically added in conjugate fashion to cyclohexenone without resorting to protection of the free NH. Comparison is made with alkylations of methyl hippurate.
Bibliographical noteFunding Information:
This investigation was supported by PHS Grant No. 24056 awarded by the National Cancer Institute.