Amino acid phosphoramidate nucleosides: potential ADEPT/GDEPT substrates.

E. J. McIntee; C. R. Wagner

doi:10.1016/S0960-894X(01)00513-3

Amino acid phosphoramidate nucleosides: potential ADEPT/GDEPT substrates.

E. J. McIntee, C. R. Wagner

Medicinal Chemistry

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Abstract

A series of aromatic, serum-stable, water soluble and nontoxic amino acid phosphoramidate monoesters of 5-fluoro-2'-deoxyuridine (FUdR) and 1-beta-arabinofuranosylcytosine (Ara-C) was shown to inhibit the cellular growth of the human leukemia cell line CCRF-CEM in the presence of human prostatic acid phosphatase (hPAP).

Original language	English (US)
Pages (from-to)	2803-2805
Number of pages	3
Journal	Bioorganic & medicinal chemistry letters
Volume	11
Issue number	21
DOIs	https://doi.org/10.1016/S0960-894X(01)00513-3
State	Published - Nov 5 2001

Bibliographical note

Funding Information:
This work was partially supported by Grant CA-61909 and the University of Minnesota Graduate School (C.R.W.). E.J.M. was supported by the National Institutes of Health Pharmacological Sciences Training Grant GM-07994.

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title = "Amino acid phosphoramidate nucleosides: potential ADEPT/GDEPT substrates.",

abstract = "A series of aromatic, serum-stable, water soluble and nontoxic amino acid phosphoramidate monoesters of 5-fluoro-2'-deoxyuridine (FUdR) and 1-beta-arabinofuranosylcytosine (Ara-C) was shown to inhibit the cellular growth of the human leukemia cell line CCRF-CEM in the presence of human prostatic acid phosphatase (hPAP).",

author = "McIntee, {E. J.} and Wagner, {C. R.}",

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AU - Wagner, C. R.

N1 - Funding Information: This work was partially supported by Grant CA-61909 and the University of Minnesota Graduate School (C.R.W.). E.J.M. was supported by the National Institutes of Health Pharmacological Sciences Training Grant GM-07994.

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AB - A series of aromatic, serum-stable, water soluble and nontoxic amino acid phosphoramidate monoesters of 5-fluoro-2'-deoxyuridine (FUdR) and 1-beta-arabinofuranosylcytosine (Ara-C) was shown to inhibit the cellular growth of the human leukemia cell line CCRF-CEM in the presence of human prostatic acid phosphatase (hPAP).

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Amino acid phosphoramidate nucleosides: potential ADEPT/GDEPT substrates.

Abstract

Bibliographical note

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