A series of aromatic, serum-stable, water soluble and nontoxic amino acid phosphoramidate monoesters of 5-fluoro-2'-deoxyuridine (FUdR) and 1-beta-arabinofuranosylcytosine (Ara-C) was shown to inhibit the cellular growth of the human leukemia cell line CCRF-CEM in the presence of human prostatic acid phosphatase (hPAP).
Bibliographical noteFunding Information:
This work was partially supported by Grant CA-61909 and the University of Minnesota Graduate School (C.R.W.). E.J.M. was supported by the National Institutes of Health Pharmacological Sciences Training Grant GM-07994.