Amyloid in the pancreatic islets of the cougar (Felis concolor) is derived from islet amyloid polypeptide (IAPP)

Kenneth H. Johnson, Christer Wernsted, Timothy D. O'Brien, Per Westermark

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

1. 1. Islet amyloid isolated from the pancreas of a 20-year-old cougar (Felis concolor) was dissolved and purified by gel permeation and reversed phase HPLC mino acid sequence analysis. 2. 2. N-Terminal amino acid sequence analysis of the purified protein revealed a primary structure (positions 1-28) identical to islet amyloid polypeptide (IAPP) from domesticated cats. 3. 3. IAPP from the cougar, like IAPP from the human and domesticated cat, incorporates an inherently amyloidogenic AILS sequence at positions 25-28.

Original languageEnglish (US)
Pages (from-to)115-119
Number of pages5
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Volume98
Issue number1
DOIs
StatePublished - 1991

Bibliographical note

Funding Information:
Acknowledgements--This work was supportedb y Grant ROI DK36734o f the National Institoutfe D iabeteas nd Digestivea nd Kidney Disease, the SweMdeisdhi calR e-search Council (Project5 N9o4.1 )t,h e Nordic Insulin Fund, and A. Louis-Hansen's Memorial Fund. The authors wish to thankK athyJ ordan,K athyB urg, and Christer Bergman for their technicaasls istance.

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