An anthraquinone with potent quinone reductase-inducing activity and other constituents of the fruits of Morinda citrifolia (Noni)

Alison D. Pawlus, Bao Ning Su, William J. Keller, A. Douglas Kinghorn

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

Morinda citrifolia, commonly known as noni, has ȧ long history of utilization throughout much of tropical Polynesia and is considered to be the second most important medicinal plant in the Hawaiian Islands. Recently, the use of noni as a dietary supplement in the United States has greatly increased. Bioassay-guided fractionation of a dichloromethane-soluble partition of a MeOH extract of noni fruits has led to the isolation of an extremely potent quinone reductase inducer, 2-methoxy-1,3,6-trihydroxyanthraquinone (1). This new anthraquinone (1) was nearly 40 times more potent than a positive control, L-sulforaphane. Furthermore, compound 1 demonstrated no discernible cytotoxicity at the highest dose tested. In addition to compound 1, 11 known compounds were also isolated and identified in the present investigation. This is the first report of the isolation of anthraquinones from noni fruits.

Original languageEnglish (US)
Pages (from-to)1720-1722
Number of pages3
JournalJournal of Natural Products
Volume68
Issue number12
DOIs
StatePublished - Dec 1 2005

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