TY - GEN
T1 - An approach to optimal individualized warfarin treatment through clinical trial simulations
AU - Chi, Chih Lin
AU - Fusaro, Vincent A.
AU - Patil, Prasad
AU - Crawford, Matthew A.
AU - Contant, Charles F.
AU - Tonellato, Peter J.
PY - 2010
Y1 - 2010
N2 - Personalized medicine will depend on sophisticated tools, analyses, and molecular level data and clinical information to provide optimized treatment based on each patient's individual characteristics such as health history, current health or disease status, and biochemical and physiological makeup. We discuss an approach to integrate clinical trial simulations with an optimization method to produce predictions of the best individualized treatment. Our objective is to optimize the treatment protocol by minimizing health risk to adverse drug reactions. This approach anticipates the era of genome-based medicine that requires sophisticated engineering, mathematical modeling and simulations to support best practice and clinical use of genetic data.
AB - Personalized medicine will depend on sophisticated tools, analyses, and molecular level data and clinical information to provide optimized treatment based on each patient's individual characteristics such as health history, current health or disease status, and biochemical and physiological makeup. We discuss an approach to integrate clinical trial simulations with an optimization method to produce predictions of the best individualized treatment. Our objective is to optimize the treatment protocol by minimizing health risk to adverse drug reactions. This approach anticipates the era of genome-based medicine that requires sophisticated engineering, mathematical modeling and simulations to support best practice and clinical use of genetic data.
KW - Clinical trial simulation
KW - Optimized treatment
KW - Personalize medicine
KW - Warfarin
UR - http://www.scopus.com/inward/record.url?scp=79952546103&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952546103&partnerID=8YFLogxK
U2 - 10.1109/CIBEC.2010.5716052
DO - 10.1109/CIBEC.2010.5716052
M3 - Conference contribution
AN - SCOPUS:79952546103
SN - 9781424471706
T3 - 2010 5th Cairo International Biomedical Engineering Conference, CIBEC 2010
SP - 116
EP - 120
BT - 2010 5th Cairo International Biomedical Engineering Conference, CIBEC 2010
T2 - 2010 5th Cairo International Biomedical Engineering Conference, CIBEC 2010
Y2 - 16 December 2010 through 18 December 2010
ER -