An approach to optimal individualized warfarin treatment through clinical trial simulations

Chih Lin Chi, Vincent A. Fusaro, Prasad Patil, Matthew A. Crawford, Charles F. Contant, Peter J. Tonellato

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Personalized medicine will depend on sophisticated tools, analyses, and molecular level data and clinical information to provide optimized treatment based on each patient's individual characteristics such as health history, current health or disease status, and biochemical and physiological makeup. We discuss an approach to integrate clinical trial simulations with an optimization method to produce predictions of the best individualized treatment. Our objective is to optimize the treatment protocol by minimizing health risk to adverse drug reactions. This approach anticipates the era of genome-based medicine that requires sophisticated engineering, mathematical modeling and simulations to support best practice and clinical use of genetic data.

Original languageEnglish (US)
Title of host publication2010 5th Cairo International Biomedical Engineering Conference, CIBEC 2010
Pages116-120
Number of pages5
DOIs
StatePublished - Dec 1 2010
Event2010 5th Cairo International Biomedical Engineering Conference, CIBEC 2010 - Cairo, Egypt
Duration: Dec 16 2010Dec 18 2010

Publication series

Name2010 5th Cairo International Biomedical Engineering Conference, CIBEC 2010

Other

Other2010 5th Cairo International Biomedical Engineering Conference, CIBEC 2010
CountryEgypt
CityCairo
Period12/16/1012/18/10

Keywords

  • Clinical trial simulation
  • Optimized treatment
  • Personalize medicine
  • Warfarin

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