An autoradiographic study in μ-opioid receptor knockout mice

Hung Chun Chen; Virginia S. Seybold; Horace H. Loh

doi:10.1016/S0169-328X(99)00346-0

An autoradiographic study in μ-opioid receptor knockout mice

Hung Chun Chen, Virginia S. Seybold, Horace H. Loh

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Abstract

An autoradiographic study was carried out to study the opioid binding sites in a μ-opioid receptor knock-out mouse line whose exon 2 and 3 were deleted. μ-Opioid binding sites were undetectable in this knock-out mouse line while the binding of the other two types of receptors were unaltered. Our results suggest destroying functional μ-opioid receptor does not affect the expression of the other two opioid receptors. Copyright (C) 2000 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	170-172
Number of pages	3
Journal	Molecular Brain Research
Volume	76
Issue number	1
DOIs	https://doi.org/10.1016/S0169-328X(99)00346-0
State	Published - Mar 10 2000

Bibliographical note

Funding Information:
This research was supported by National Institutes of Health research grants DA00564, DA01583, DA11806, DA70554 and the F. and A. Stark Fund of the Minnesota Medical Foundation.

Keywords

Autoradiography
Knock-out mice
Opioid receptor

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title = "An autoradiographic study in μ-opioid receptor knockout mice",

abstract = "An autoradiographic study was carried out to study the opioid binding sites in a μ-opioid receptor knock-out mouse line whose exon 2 and 3 were deleted. μ-Opioid binding sites were undetectable in this knock-out mouse line while the binding of the other two types of receptors were unaltered. Our results suggest destroying functional μ-opioid receptor does not affect the expression of the other two opioid receptors. Copyright (C) 2000 Elsevier Science B.V.",

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AU - Seybold, Virginia S.

AU - Loh, Horace H.

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N2 - An autoradiographic study was carried out to study the opioid binding sites in a μ-opioid receptor knock-out mouse line whose exon 2 and 3 were deleted. μ-Opioid binding sites were undetectable in this knock-out mouse line while the binding of the other two types of receptors were unaltered. Our results suggest destroying functional μ-opioid receptor does not affect the expression of the other two opioid receptors. Copyright (C) 2000 Elsevier Science B.V.

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KW - Opioid receptor

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An autoradiographic study in μ-opioid receptor knockout mice

Abstract

Bibliographical note

Keywords

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