Abstract
An autoradiographic study was carried out to study the opioid binding sites in a μ-opioid receptor knock-out mouse line whose exon 2 and 3 were deleted. μ-Opioid binding sites were undetectable in this knock-out mouse line while the binding of the other two types of receptors were unaltered. Our results suggest destroying functional μ-opioid receptor does not affect the expression of the other two opioid receptors. Copyright (C) 2000 Elsevier Science B.V.
Original language | English (US) |
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Pages (from-to) | 170-172 |
Number of pages | 3 |
Journal | Molecular Brain Research |
Volume | 76 |
Issue number | 1 |
DOIs | |
State | Published - Mar 10 2000 |
Bibliographical note
Funding Information:This research was supported by National Institutes of Health research grants DA00564, DA01583, DA11806, DA70554 and the F. and A. Stark Fund of the Minnesota Medical Foundation.
Keywords
- Autoradiography
- Knock-out mice
- Opioid receptor