An autoradiographic study was carried out to study the opioid binding sites in a μ-opioid receptor knock-out mouse line whose exon 2 and 3 were deleted. μ-Opioid binding sites were undetectable in this knock-out mouse line while the binding of the other two types of receptors were unaltered. Our results suggest destroying functional μ-opioid receptor does not affect the expression of the other two opioid receptors. Copyright (C) 2000 Elsevier Science B.V.
Bibliographical noteFunding Information:
This research was supported by National Institutes of Health research grants DA00564, DA01583, DA11806, DA70554 and the F. and A. Stark Fund of the Minnesota Medical Foundation.
Copyright 2018 Elsevier B.V., All rights reserved.
- Knock-out mice
- Opioid receptor