An efficient boric acid-mediated preparation of α-hydroxyamides

J. Sravan Kumar; Subash C. Jonnalagadda; Venkatram R. Mereddy

doi:10.1016/j.tetlet.2009.12.008

An efficient boric acid-mediated preparation of α-hydroxyamides

J. Sravan Kumar, Subash C. Jonnalagadda, Venkatram R. Mereddy

Duluth Pharmacy Program

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

An efficient methodology for the preparation of α-hydroxyamides via boric acid-mediated addition of isonitriles onto aldehydes has been developed. The reaction of isonitriles with α-boronobenzaldehyde takes place under intramolecular catalysis conditions to provide functionalized benzoxaboroles.

Original language	English (US)
Pages (from-to)	779-782
Number of pages	4
Journal	Tetrahedron Letters
Volume	51
Issue number	5
DOIs	https://doi.org/10.1016/j.tetlet.2009.12.008
State	Published - Feb 3 2010

Keywords

Benzoxaboroles
Boric acid
Isonitriles
Multicomponent reactions

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abstract = "An efficient methodology for the preparation of α-hydroxyamides via boric acid-mediated addition of isonitriles onto aldehydes has been developed. The reaction of isonitriles with α-boronobenzaldehyde takes place under intramolecular catalysis conditions to provide functionalized benzoxaboroles.",

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AB - An efficient methodology for the preparation of α-hydroxyamides via boric acid-mediated addition of isonitriles onto aldehydes has been developed. The reaction of isonitriles with α-boronobenzaldehyde takes place under intramolecular catalysis conditions to provide functionalized benzoxaboroles.

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KW - Boric acid

KW - Isonitriles

KW - Multicomponent reactions

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An efficient boric acid-mediated preparation of α-hydroxyamides

Abstract

Keywords

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