An evaluation of multiple phenotypic screening methods for Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae

Elizabeth B. Hirsch, Kai Tai Chang, Paola C. Zucchi, Dennis N. Francoeur, Kimberly R. Ledesma, Vincent H. Tamb, Todd M. Lasco

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae may display MICs to carbapenems within susceptible or intermediate ranges, prompting confirmatory testing. Four phenotypic methods to detect KPC producers were evaluated against a collection of clinical Enterobacteriaceae isolates. Meropenemephenylboronic acid double disk synergy testing demonstrated the best performance with 100% sensitivity and specificity.

Original languageEnglish (US)
Pages (from-to)224-227
Number of pages4
JournalJournal of Infection and Chemotherapy
Volume20
Issue number3
DOIs
StatePublished - Mar 2014
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported in part by the St. Luke's Episcopal Hospital's Roderick D. MacDonald Research Fund .

Keywords

  • CRE
  • Carbapenem
  • Chromogenic agar
  • Modified Hodge test
  • Phenylboronic acid

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