Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae may display MICs to carbapenems within susceptible or intermediate ranges, prompting confirmatory testing. Four phenotypic methods to detect KPC producers were evaluated against a collection of clinical Enterobacteriaceae isolates. Meropenemephenylboronic acid double disk synergy testing demonstrated the best performance with 100% sensitivity and specificity.
Bibliographical noteFunding Information:
This study was supported in part by the St. Luke's Episcopal Hospital's Roderick D. MacDonald Research Fund .
- Chromogenic agar
- Modified Hodge test
- Phenylboronic acid