An evaluation of multiple phenotypic screening methods for Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae

Elizabeth B. Hirsch; Kai Tai Chang; Paola C. Zucchi; Dennis N. Francoeur; Kimberly R. Ledesma; Vincent H. Tamb; Todd M. Lasco

doi:10.1016/j.jiac.2013.10.011

An evaluation of multiple phenotypic screening methods for Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae

Elizabeth B. Hirsch, Kai Tai Chang, Paola C. Zucchi, Dennis N. Francoeur, Kimberly R. Ledesma, Vincent H. Tamb, Todd M. Lasco

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae may display MICs to carbapenems within susceptible or intermediate ranges, prompting confirmatory testing. Four phenotypic methods to detect KPC producers were evaluated against a collection of clinical Enterobacteriaceae isolates. Meropenemephenylboronic acid double disk synergy testing demonstrated the best performance with 100% sensitivity and specificity.

Original language	English (US)
Pages (from-to)	224-227
Number of pages	4
Journal	Journal of Infection and Chemotherapy
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/j.jiac.2013.10.011
State	Published - Mar 2014
Externally published	Yes

Bibliographical note

Funding Information:
This study was supported in part by the St. Luke's Episcopal Hospital's Roderick D. MacDonald Research Fund .

Keywords

CRE
Carbapenem
Chromogenic agar
Modified Hodge test
Phenylboronic acid

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jiac.2013.10.011

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title = "An evaluation of multiple phenotypic screening methods for Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae",

abstract = "Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae may display MICs to carbapenems within susceptible or intermediate ranges, prompting confirmatory testing. Four phenotypic methods to detect KPC producers were evaluated against a collection of clinical Enterobacteriaceae isolates. Meropenemephenylboronic acid double disk synergy testing demonstrated the best performance with 100% sensitivity and specificity.",

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note = "Funding Information: This study was supported in part by the St. Luke's Episcopal Hospital's Roderick D. MacDonald Research Fund . ",

year = "2014",

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doi = "10.1016/j.jiac.2013.10.011",

language = "English (US)",

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AU - Hirsch, Elizabeth B.

AU - Chang, Kai Tai

AU - Zucchi, Paola C.

AU - Francoeur, Dennis N.

AU - Ledesma, Kimberly R.

AU - Tamb, Vincent H.

AU - Lasco, Todd M.

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PY - 2014/3

Y1 - 2014/3

N2 - Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae may display MICs to carbapenems within susceptible or intermediate ranges, prompting confirmatory testing. Four phenotypic methods to detect KPC producers were evaluated against a collection of clinical Enterobacteriaceae isolates. Meropenemephenylboronic acid double disk synergy testing demonstrated the best performance with 100% sensitivity and specificity.

AB - Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae may display MICs to carbapenems within susceptible or intermediate ranges, prompting confirmatory testing. Four phenotypic methods to detect KPC producers were evaluated against a collection of clinical Enterobacteriaceae isolates. Meropenemephenylboronic acid double disk synergy testing demonstrated the best performance with 100% sensitivity and specificity.

KW - CRE

KW - Carbapenem

KW - Chromogenic agar

KW - Modified Hodge test

KW - Phenylboronic acid

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JO - Journal of Infection and Chemotherapy

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ER -

An evaluation of multiple phenotypic screening methods for Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae

Abstract

Bibliographical note

Keywords

UN SDGs

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