An evidence-based review of the current treatment of congenital diaphragmatic hernia

Junaid Haroon, Ronald S. Chamberlain

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

Congenital diaphragmatic hernia is a rare but severe condition affecting 1 in 2000 to 3000 newborns with a survival rate of 67%. Although regular antenatal screening allows prenatal diagnosis in many cases, traditionally treatment has been based on postnatal surgical repair. Recent literature has pointed out the survival benefits of initial stabilization and the use of gentle ventilation strategies prior to definitive treatment, shifting the trend from immediate to delayed surgical repair. Advances in fetal intervention have allowed the introduction of fetal endoscopic tracheal occlusion as a method to hasten lung development before birth in order to minimize postnatal morbidity. Despite appropriate treatment, the long-term outcomes of these patients are plagued with numerous complications, associated with the primary pathology and also aggressive therapeutic measures. International centers of excellence have recently come together in an effort to standardize the care of such patients in hopes of maximizing their outcomes.

Original languageEnglish (US)
Pages (from-to)115-124
Number of pages10
JournalClinical Pediatrics
Volume52
Issue number2
DOIs
StatePublished - Feb 1 2013

Keywords

  • Bochdalek hernia
  • ECMO
  • FETO
  • Morgagni hernia
  • congenital diaphragmatic hernia
  • embryology
  • patch repair
  • surgery

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