TY - JOUR
T1 - An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma
AU - Hron, Alexander J.
AU - Asakura, Atsushi
N1 - Funding Information:
NIH R01 (1R01AR062142) and NIH R21 (1R21AR070319).
Publisher Copyright:
© 2017 Alexander Hron and Atsushi Asakura.
PY - 2017
Y1 - 2017
N2 - Rhabdomyosarcoma (RMS) is an aggressive family of soft tissue tumors that most commonly manifests in children. RMS variants express several skeletal muscle markers, suggesting myogenic stem or progenitor cell origin of RMS. In this review, the roles of both recently identified and well-established microRNAs in RMS are discussed and summarized in a succinct, tabulated format. Additionally, the subtypes of RMS are reviewed along with the involvement of basic helix-loop-helix (bHLH) proteins, Pax proteins, and microRNAs in normal and pathologic myogenesis. Finally, the current and potential future treatment options for RMS are outlined.
AB - Rhabdomyosarcoma (RMS) is an aggressive family of soft tissue tumors that most commonly manifests in children. RMS variants express several skeletal muscle markers, suggesting myogenic stem or progenitor cell origin of RMS. In this review, the roles of both recently identified and well-established microRNAs in RMS are discussed and summarized in a succinct, tabulated format. Additionally, the subtypes of RMS are reviewed along with the involvement of basic helix-loop-helix (bHLH) proteins, Pax proteins, and microRNAs in normal and pathologic myogenesis. Finally, the current and potential future treatment options for RMS are outlined.
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U2 - 10.1155/2017/2480375
DO - 10.1155/2017/2480375
M3 - Review article
C2 - 28638414
AN - SCOPUS:85021631553
SN - 1687-9678
VL - 2017
JO - Stem Cells International
JF - Stem Cells International
M1 - 2480375
ER -