An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma

Alexander J. Hron, Atsushi Asakura

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Rhabdomyosarcoma (RMS) is an aggressive family of soft tissue tumors that most commonly manifests in children. RMS variants express several skeletal muscle markers, suggesting myogenic stem or progenitor cell origin of RMS. In this review, the roles of both recently identified and well-established microRNAs in RMS are discussed and summarized in a succinct, tabulated format. Additionally, the subtypes of RMS are reviewed along with the involvement of basic helix-loop-helix (bHLH) proteins, Pax proteins, and microRNAs in normal and pathologic myogenesis. Finally, the current and potential future treatment options for RMS are outlined.

Original languageEnglish (US)
Article number2480375
JournalStem Cells International
Volume2017
DOIs
StatePublished - 2017

Bibliographical note

Funding Information:
NIH R01 (1R01AR062142) and NIH R21 (1R21AR070319).

Publisher Copyright:
© 2017 Alexander Hron and Atsushi Asakura.

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