An excitatory amino acid antagonist blocks cone input to sign-conserving second-order retinal neurons

Malcolm M. Slaughter, Robert F. Miller

Research output: Contribution to journalArticlepeer-review

161 Scopus citations

Abstract

cis-2,3-Piperidinedicarboxylic acid (PDA), an excitatory amino acid antagonist, reversibly blocked cone input to OFF bipolars and horizontal cells, whereas ON bipolars were relatively unaffected. Kainic acid effects were also blocked, indicating a postsynaptic mechanism of action. The use of PDA helps to characterize one of two classes of excitatory amino acid synaptic receptors that mediate cone influence in the outer retina.

Original languageEnglish (US)
Pages (from-to)1230-1232
Number of pages3
JournalScience
Volume219
Issue number4589
DOIs
StatePublished - 1983

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