An expanded role for mTORC1 in autophagy

Young Mi Kim; Ji Man Park; Douglas Grunwald; Do Hyung Kim

doi:10.1080/23723556.2015.1010958

An expanded role for mTORC1 in autophagy

Young Mi Kim, Ji Man Park, Douglas Grunwald, Do Hyung Kim

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9 Scopus citations

Abstract

Mechanistic target of rapamycin complex 1 (mTORC1) negatively regulates autophagy at early stages by phosphorylating Unc51-like kinase 1 (ULK1). Our recent study expanded the roles of mTORC1 in autophagy by identifying ultraviolet radiation resistance-associated gene product (UVRAG) as a substrate of mTORC1. This finding has provided new insight into the roles of mTORC1 in cellular membrane processes and cancer.

Original language	English (US)
Article number	e1010958
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1080/23723556.2015.1010958
State	Published - Jan 2 2016

Bibliographical note

Funding Information:
This study was supported by grants from the National Institutes of Health (P30- DK050456, GM097057, AG039758), U.S. Department of Defense (W81XWH- 13-1-0060), and American Diabetes Asso ciation (ADA 7-12-BS-093).

Publisher Copyright:
© 2016, © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2016, © Young-Mi Kim, Ji-Man Park, Douglas Grunwald, and Do-Hyung Kim.

Keywords

RUBICON
UVRAG
autophagy
endosome
lysosome
mTOR
mTORC1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/23723556.2015.1010958

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abstract = "Mechanistic target of rapamycin complex 1 (mTORC1) negatively regulates autophagy at early stages by phosphorylating Unc51-like kinase 1 (ULK1). Our recent study expanded the roles of mTORC1 in autophagy by identifying ultraviolet radiation resistance-associated gene product (UVRAG) as a substrate of mTORC1. This finding has provided new insight into the roles of mTORC1 in cellular membrane processes and cancer.",

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AU - Grunwald, Douglas

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An expanded role for mTORC1 in autophagy

Abstract

Bibliographical note

Keywords

UN SDGs

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