Mechanistic target of rapamycin complex 1 (mTORC1) negatively regulates autophagy at early stages by phosphorylating Unc51-like kinase 1 (ULK1). Our recent study expanded the roles of mTORC1 in autophagy by identifying ultraviolet radiation resistance-associated gene product (UVRAG) as a substrate of mTORC1. This finding has provided new insight into the roles of mTORC1 in cellular membrane processes and cancer.
Bibliographical noteFunding Information:
This study was supported by grants from the National Institutes of Health (P30- DK050456, GM097057, AG039758), U.S. Department of Defense (W81XWH- 13-1-0060), and American Diabetes Asso ciation (ADA 7-12-BS-093).
© 2016, © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2016, © Young-Mi Kim, Ji-Man Park, Douglas Grunwald, and Do-Hyung Kim.
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