An improved synthesis of radiolabeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone

Lisa A. Peterson; Thomas E. Spratt; Weifeng Shan; Lijuan Wang; Witold Subotkowski; Robert Roth

doi:10.1002/jlcr.469

An improved synthesis of radiolabeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone

Lisa A. Peterson, Thomas E. Spratt, Weifeng Shan, Lijuan Wang, Witold Subotkowski, Robert Roth

Environmental Health Sciences

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The synthesis of high specific activity tritium-labeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone is reported. This compound was prepared by tritiation of 4-(acetoxymethylnitrosamino)-1-[3-(5-bromo)-pyridyl]-1-butanone (5-BrNNKOAc) in the presence of 10% Pd/C catalyst, yielding a product with a specific activity of 11.9 Ci/mmol. This pathway represents a major improvement over previously published methods.

Original language	English (US)
Pages (from-to)	445-450
Number of pages	6
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	44
Issue number	6
DOIs	https://doi.org/10.1002/jlcr.469
State	Published - 2001

Keywords

NNK
NNN and NNKOAc
Tobacco-specific nitrosamines

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title = "An improved synthesis of radiolabeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone",

abstract = "The synthesis of high specific activity tritium-labeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone is reported. This compound was prepared by tritiation of 4-(acetoxymethylnitrosamino)-1-[3-(5-bromo)-pyridyl]-1-butanone (5-BrNNKOAc) in the presence of 10% Pd/C catalyst, yielding a product with a specific activity of 11.9 Ci/mmol. This pathway represents a major improvement over previously published methods.",

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year = "2001",

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T1 - An improved synthesis of radiolabeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone

AU - Peterson, Lisa A.

AU - Spratt, Thomas E.

AU - Shan, Weifeng

AU - Wang, Lijuan

AU - Subotkowski, Witold

AU - Roth, Robert

PY - 2001

Y1 - 2001

N2 - The synthesis of high specific activity tritium-labeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone is reported. This compound was prepared by tritiation of 4-(acetoxymethylnitrosamino)-1-[3-(5-bromo)-pyridyl]-1-butanone (5-BrNNKOAc) in the presence of 10% Pd/C catalyst, yielding a product with a specific activity of 11.9 Ci/mmol. This pathway represents a major improvement over previously published methods.

AB - The synthesis of high specific activity tritium-labeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone is reported. This compound was prepared by tritiation of 4-(acetoxymethylnitrosamino)-1-[3-(5-bromo)-pyridyl]-1-butanone (5-BrNNKOAc) in the presence of 10% Pd/C catalyst, yielding a product with a specific activity of 11.9 Ci/mmol. This pathway represents a major improvement over previously published methods.

KW - NNK

KW - NNN and NNKOAc

KW - Tobacco-specific nitrosamines

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An improved synthesis of radiolabeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone

Abstract

Keywords

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