TY - JOUR
T1 - An increase in chromogranin A-positive, hormone-negative endocrine cells in pancreas in cystic fibrosis
AU - Cory, Megan
AU - Md Moin, Abu Saleh
AU - Moran, Antoinette
AU - Rizza, Robert A.
AU - Butler, Peter C.
AU - Dhawan, Sangeeta
AU - Butler, Alexandra E.
N1 - Publisher Copyright:
© 2018 Endocrine Society.
PY - 2018/9
Y1 - 2018/9
N2 - We sought to establish whether an increase in chromogranin A-positive, hormone-negative (CPHN) endocrine cells occurs in the pancreas of patients with cystic fibrosis (CF), as potential evidence of neogenesis. Pancreata were obtained at autopsy from nondiabetic patients with CF (n = 12) and age-matched nondiabetic control subject (CS) individuals without CF (n = 12). In addition, pancreas from three diabetic patients with CF was obtained. Pancreas sections were stained for chromogranin A, insulin, and a cocktail of glucagon, somatostatin, pancreatic polypeptide, and ghrelin and evaluated for the frequency of CPHN cells. There was a higher frequency of CPHN cells in islets of the patients with CF compared with the CS group. Moreover, CPHN cells occurring as single cells or clusters scattered in the exocrine pancreas were also more frequent in patients with CF. The increased frequency of CPHN cells in pancreas of patients with CF may indicate an attempt at endocrine cell regeneration.
AB - We sought to establish whether an increase in chromogranin A-positive, hormone-negative (CPHN) endocrine cells occurs in the pancreas of patients with cystic fibrosis (CF), as potential evidence of neogenesis. Pancreata were obtained at autopsy from nondiabetic patients with CF (n = 12) and age-matched nondiabetic control subject (CS) individuals without CF (n = 12). In addition, pancreas from three diabetic patients with CF was obtained. Pancreas sections were stained for chromogranin A, insulin, and a cocktail of glucagon, somatostatin, pancreatic polypeptide, and ghrelin and evaluated for the frequency of CPHN cells. There was a higher frequency of CPHN cells in islets of the patients with CF compared with the CS group. Moreover, CPHN cells occurring as single cells or clusters scattered in the exocrine pancreas were also more frequent in patients with CF. The increased frequency of CPHN cells in pancreas of patients with CF may indicate an attempt at endocrine cell regeneration.
KW - Cystic fibrosis
KW - Inflammation
KW - β cell
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U2 - 10.1210/JS.2018-00143
DO - 10.1210/JS.2018-00143
M3 - Article
AN - SCOPUS:85073665686
SN - 2472-1972
VL - 2
SP - 1058
EP - 1066
JO - Journal of the Endocrine Society
JF - Journal of the Endocrine Society
IS - 9
ER -