An organo-catalytic approach to the enantioselective synthesis of (R)-selegiline

Siva Kumar Talluri, Arumugam Sudalai

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29 Scopus citations

Abstract

An efficient enantioselective synthesis of (R)-selegiline has been achieved by two routes, via proline-catalyzed α-aminooxylation as well as α-amination of phenylpropanaldehyde as the key step.

Original languageEnglish (US)
Pages (from-to)9758-9763
Number of pages6
JournalTetrahedron
Volume63
Issue number39
DOIs
StatePublished - Sep 24 2007

Bibliographical note

Funding Information:
S.K.T. thanks CSIR, New Delhi, for financial support. The authors thank Dr. B. D. Kulkarni, Head, CE-PD Division, for his constant encouragement and support.

Keywords

  • Asymmetric reactions
  • Organocatalysis
  • Proline
  • α-Amination
  • α-Aminooxylation

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