An ultra acid stable reversed stationary phase

Brian C. Trammell, Lianjia Ma, Hao Luo, Marc A. Hillmyer, Peter W. Carr

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

We report anew reversed phase liquid chromatography (RPLC) phase with remarkable acid stability using dimethyl(ethylphenylchloromethyl)chlorosilane (1), oligomeric polystyrene (PS), and octylbenzene (C8). This phase Si-1-PS-C8 was prepared using silica modification processes and Friedel-Crafts alkylation chemistry. Under highly aggressive mobile phase conditions, Si-1-PS-C8 exhibited remarkable stability as evinced by only minimal reduction in retention factor (k′) after 1400 column volumes at pH = 0.5 and 150 °C. The peak shapes for a variety of basic solutes were symmetric using Si-1-PS-C8. Evidence for a highly cross-linked coating of the silica particles was observed using scanning electron microscopy. The remarkable stability of this phase is unparalleled as compared to all other RPLC phases reported to date.

Original languageEnglish (US)
Pages (from-to)10504-10505
Number of pages2
JournalJournal of the American Chemical Society
Volume125
Issue number35
DOIs
StatePublished - Sep 3 2003

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