Analgesic use during pregnancy and risk of infant leukaemia: A Children's Oncology Group study

S. Ognjanovic; Cindy K. Blair; Logan G. Spector; Leslie L. Robison; M. Roesler; Julie A. Ross

doi:10.1038/sj.bjc.6606046

Analgesic use during pregnancy and risk of infant leukaemia: A Children's Oncology Group study

S. Ognjanovic, Cindy K. Blair, Logan G. Spector, Leslie L. Robison, M. Roesler, Julie A. Ross

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Abstract

BACKGROUND: Infant leukaemia is likely initiated in utero.\n\nMETHODS: We examined whether analgesic use during pregnancy was associated with risk by completing telephone interviews of the mothers of 441 infant leukaemia cases and 323 frequency-matched controls, using unconditional logistic regression.\n\nRESULTS: With the exception of a reduced risk for infant acute myeloid leukaemias with non-aspirin non-steroidal anti-inflammatory drugs (NSAID) use early in pregnancy (odds ratios=0.60; confidence intervals: 0.37-0.97), no statistically significant associations were observed for aspirin, non-aspirin NSAIDs, or acetaminophen use in early pregnancy or after knowledge of pregnancy.\n\nCONCLUSION: Overall, analgesic use during pregnancy was not significantly associated with the risk of infant leukaemia.

Original language	English (US)
Journal	British Journal of Cancer
Volume	104
DOIs	https://doi.org/10.1038/sj.bjc.6606046
State	Published - 2011

Keywords

epidemiology
analgesics
infants
leukaemia

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title = "Analgesic use during pregnancy and risk of infant leukaemia: A Children's Oncology Group study",

abstract = "BACKGROUND: Infant leukaemia is likely initiated in utero.\n\nMETHODS: We examined whether analgesic use during pregnancy was associated with risk by completing telephone interviews of the mothers of 441 infant leukaemia cases and 323 frequency-matched controls, using unconditional logistic regression.\n\nRESULTS: With the exception of a reduced risk for infant acute myeloid leukaemias with non-aspirin non-steroidal anti-inflammatory drugs (NSAID) use early in pregnancy (odds ratios=0.60; confidence intervals: 0.37-0.97), no statistically significant associations were observed for aspirin, non-aspirin NSAIDs, or acetaminophen use in early pregnancy or after knowledge of pregnancy.\n\nCONCLUSION: Overall, analgesic use during pregnancy was not significantly associated with the risk of infant leukaemia.",

keywords = "epidemiology, analgesics, infants, leukaemia",

author = "S. Ognjanovic and Blair, {Cindy K.} and Spector, {Logan G.} and Robison, {Leslie L.} and M. Roesler and Ross, {Julie A.}",

year = "2011",

doi = "10.1038/sj.bjc.6606046",

language = "English (US)",

volume = "104",

journal = "British Journal of Cancer",

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T1 - Analgesic use during pregnancy and risk of infant leukaemia: A Children's Oncology Group study

AU - Ognjanovic, S.

AU - Blair, Cindy K.

AU - Spector, Logan G.

AU - Robison, Leslie L.

AU - Roesler, M.

AU - Ross, Julie A.

PY - 2011

Y1 - 2011

N2 - BACKGROUND: Infant leukaemia is likely initiated in utero.\n\nMETHODS: We examined whether analgesic use during pregnancy was associated with risk by completing telephone interviews of the mothers of 441 infant leukaemia cases and 323 frequency-matched controls, using unconditional logistic regression.\n\nRESULTS: With the exception of a reduced risk for infant acute myeloid leukaemias with non-aspirin non-steroidal anti-inflammatory drugs (NSAID) use early in pregnancy (odds ratios=0.60; confidence intervals: 0.37-0.97), no statistically significant associations were observed for aspirin, non-aspirin NSAIDs, or acetaminophen use in early pregnancy or after knowledge of pregnancy.\n\nCONCLUSION: Overall, analgesic use during pregnancy was not significantly associated with the risk of infant leukaemia.

AB - BACKGROUND: Infant leukaemia is likely initiated in utero.\n\nMETHODS: We examined whether analgesic use during pregnancy was associated with risk by completing telephone interviews of the mothers of 441 infant leukaemia cases and 323 frequency-matched controls, using unconditional logistic regression.\n\nRESULTS: With the exception of a reduced risk for infant acute myeloid leukaemias with non-aspirin non-steroidal anti-inflammatory drugs (NSAID) use early in pregnancy (odds ratios=0.60; confidence intervals: 0.37-0.97), no statistically significant associations were observed for aspirin, non-aspirin NSAIDs, or acetaminophen use in early pregnancy or after knowledge of pregnancy.\n\nCONCLUSION: Overall, analgesic use during pregnancy was not significantly associated with the risk of infant leukaemia.

KW - epidemiology

KW - analgesics

KW - infants

KW - leukaemia

U2 - 10.1038/sj.bjc.6606046

DO - 10.1038/sj.bjc.6606046

M3 - Article

SN - 0007-0920

VL - 104

JO - British Journal of Cancer

JF - British Journal of Cancer

ER -

Analgesic use during pregnancy and risk of infant leukaemia: A Children's Oncology Group study

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