TY - GEN
T1 - Analysis of high-throughput DNA methylation bead arrays utilizing bayesian genotyping algorithms
AU - Xiao, Yuanyuan
AU - Segal, Mark R.
AU - Houseman, E. Andres
AU - Wiemels, Joe
AU - Wiencke, John
AU - Zheng, Shichun
AU - Wrensch, Margaret
AU - Christensen, Brock
AU - Marsit, Carmen
AU - Kelsey, Karl
AU - Nelson, Heather
AU - Karagas, Margaret
AU - Yeh, Ru Fang
PY - 2008/9/17
Y1 - 2008/9/17
N2 - We present a statistical framework, MAMS-M, for determining the methylation status of hundreds of cancer related CpG sites. MAMS-M extends and adapts our previous SNP genotyping algorithm, MAMS, to methylation bead array data, exploiting the similarities in data structure between the two platforms. MAMS-M employs a multi-site, multi-array model-based clustering approach to derive initial methylation calls, and then recalibrate these calls and associated confidence measures using site-specific adjustments. We demonstrate the performance of MAMS-M using a real-life data set with cancer applications.
AB - We present a statistical framework, MAMS-M, for determining the methylation status of hundreds of cancer related CpG sites. MAMS-M extends and adapts our previous SNP genotyping algorithm, MAMS, to methylation bead array data, exploiting the similarities in data structure between the two platforms. MAMS-M employs a multi-site, multi-array model-based clustering approach to derive initial methylation calls, and then recalibrate these calls and associated confidence measures using site-specific adjustments. We demonstrate the performance of MAMS-M using a real-life data set with cancer applications.
UR - http://www.scopus.com/inward/record.url?scp=51549116448&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=51549116448&partnerID=8YFLogxK
U2 - 10.1109/BMEI.2008.150
DO - 10.1109/BMEI.2008.150
M3 - Conference contribution
AN - SCOPUS:51549116448
SN - 9780769531182
T3 - BioMedical Engineering and Informatics: New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008
SP - 447
EP - 452
BT - BioMedical Engineering and Informatics
T2 - BioMedical Engineering and Informatics: New Development and the Future - 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008
Y2 - 27 May 2008 through 30 May 2008
ER -
