Analysis of organophosphorus insecticides in biological samples by selective ion monitoring gas chromatography-mass spectrometry

Ashok K. Singh, David W. Hewetson, Kathryn C. Jordon, Muhammed Ashraf

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Gas chromatography with chemical ionization or electron impact mass spectrometry and selected ion monitoring provided a simple and sensitive method for measuring organophosphorus insecticides. Chemical ionization produced highermass ions which might increase the selectivity and sensitivity of the assay. The recovery of organophosphates from saline and urine was greater than 75%. The recovery of these compounds from plasma was less than the saline because of the binding of insecticides to plasma protein. Insecticides with lower LD50 values showed lower recovery from plasma than organophosphates with higher LD50 values.

Original languageEnglish (US)
Pages (from-to)83-96
Number of pages14
JournalJournal of Chromatography A
Volume369
Issue numberC
DOIs
StatePublished - 1986

Bibliographical note

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

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