TY - JOUR
T1 - Anaphase promoting complex or cyclosome?
AU - Clarke, Duncan J.
AU - Díaz-Martínez, Laura A.
AU - Giménez-Abián, Juan F.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2005/11
Y1 - 2005/11
N2 - The anaphase promoting complex/cyclosome (APC/C) was initially described as a multi-subunit protein complex that ubiquitinates anaphase inhibitors thus targeting them for destruction by proteasomes to initiate loss of sister chromatid cohesion. However, recent studies have identified important new functions of the APC/C. Moreover, sister centromere separation can occur in the absence of APC/C activity in mammals, indicating that anaphase onset might be triggered by multiple factors. Here we discuss whether the APC/C functions primarily as the anaphase trigger, or whether it has more general properties, relevant for cell cycle control at multiple developmental and cell cycle stages. Additionally, we discuss the validity of the APC-dependent model for sister segregation in mammals.
AB - The anaphase promoting complex/cyclosome (APC/C) was initially described as a multi-subunit protein complex that ubiquitinates anaphase inhibitors thus targeting them for destruction by proteasomes to initiate loss of sister chromatid cohesion. However, recent studies have identified important new functions of the APC/C. Moreover, sister centromere separation can occur in the absence of APC/C activity in mammals, indicating that anaphase onset might be triggered by multiple factors. Here we discuss whether the APC/C functions primarily as the anaphase trigger, or whether it has more general properties, relevant for cell cycle control at multiple developmental and cell cycle stages. Additionally, we discuss the validity of the APC-dependent model for sister segregation in mammals.
UR - http://www.scopus.com/inward/record.url?scp=34548098592&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548098592&partnerID=8YFLogxK
U2 - 10.4161/cc.4.11.2143
DO - 10.4161/cc.4.11.2143
M3 - Article
C2 - 16237278
AN - SCOPUS:27744473783
SN - 1538-4101
VL - 4
SP - 1585
EP - 1592
JO - Cell cycle (Georgetown, Tex.)
JF - Cell cycle (Georgetown, Tex.)
IS - 11
ER -