TY - JOUR
T1 - Anaphylactoid purpura
T2 - Characteristics of 16 patients who progressed to renal failure
AU - Bunchman, Timothy E.
AU - Mauer, S. Michael
AU - Sibley, Richard K.
AU - Vernier, Robert L.
PY - 1988/12
Y1 - 1988/12
N2 - Renal insufficiency occurs in at least 1.5% of children with anaphylactoid purpura (AP). We reviewed the records of 16 children who developed end-stage renal disease (ESRD group) secondary to AP and matched them for age, era of onset, renal histology, and clinical severity at onset with 16 children who has AP but whose creatinine clearance returned to and remained normal (recovery group). We reviewed creatinine clearances at 1, 3, 5, and 10 years after onset. A creatinine clearance >70 ml/min per 1.73 m2 was present in 50% of the patients in the ESRD group at 3 years and in 25% at 5 years after onset. In contrast, all patients in the recovery group had a creatinine clearance >70 ml/min per 1.73 m2 by 3 years (7 of 16 had a creatinine clearance >125 ml/min per 1.73 m2) and all were normal 95-125 ml/min per 1.73 m2) by 5 years. Thus, the presence of an increased creatinine clearance (>125 ml/min per 1.73 m2) at 3 years predicted recovery, while failure to reach a creatinine clearance of >70 ml/min per 1.73 m2 at 3 years predicted progression to ESRD. There was no evidence of recurrent systemic AP or nephritis in the 14 patients who underwent renal allograft transplantation. We conclude that long-term evaluation of patients over many years is required to identify those who will progress to ESRD from AP and that recurrence of AP in the renal transplant is uncommon.
AB - Renal insufficiency occurs in at least 1.5% of children with anaphylactoid purpura (AP). We reviewed the records of 16 children who developed end-stage renal disease (ESRD group) secondary to AP and matched them for age, era of onset, renal histology, and clinical severity at onset with 16 children who has AP but whose creatinine clearance returned to and remained normal (recovery group). We reviewed creatinine clearances at 1, 3, 5, and 10 years after onset. A creatinine clearance >70 ml/min per 1.73 m2 was present in 50% of the patients in the ESRD group at 3 years and in 25% at 5 years after onset. In contrast, all patients in the recovery group had a creatinine clearance >70 ml/min per 1.73 m2 by 3 years (7 of 16 had a creatinine clearance >125 ml/min per 1.73 m2) and all were normal 95-125 ml/min per 1.73 m2) by 5 years. Thus, the presence of an increased creatinine clearance (>125 ml/min per 1.73 m2) at 3 years predicted recovery, while failure to reach a creatinine clearance of >70 ml/min per 1.73 m2 at 3 years predicted progression to ESRD. There was no evidence of recurrent systemic AP or nephritis in the 14 patients who underwent renal allograft transplantation. We conclude that long-term evaluation of patients over many years is required to identify those who will progress to ESRD from AP and that recurrence of AP in the renal transplant is uncommon.
KW - Anaphylactoid purpura
KW - Glomerulonephritis
KW - Henoch-Schönlein purpura
KW - Renal transplantation
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U2 - 10.1007/BF00853428
DO - 10.1007/BF00853428
M3 - Article
C2 - 3153049
AN - SCOPUS:0023747550
SN - 0931-041X
VL - 2
SP - 393
EP - 397
JO - Pediatric Nephrology
JF - Pediatric Nephrology
IS - 4
ER -