Androgen receptor directed therapies in castration-resistant metastatic prostate cancer

Won Kim, Charles Ryan

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Recent results of phase III randomized studies confirm that targeting the androgen receptor (AR)-Through inhibition of androgen synthesis or through AR targeting directly-can improve survival for patients with metastatic castration-resistant prostate cancer (mCRPC), a condition previously considered to be refractory to further hormonal manipulation. These data validate in the clinical setting much of the scientific work of the previous decade that has demonstrated the extent of and mechanisms behind retained AR signaling in advanced prostate cancer. The convergence of these observations effectively changes the perspective with which androgen deprivation is utilized in prostate cancer, and forms the basis for further expansion of systemic therapy in the disease. In this review, the rationale for and clinical results with these new therapieswill be discussed as will the future directions required to fully leverage these therapeutic modalities to the maximum clinical benefit for patients.

Original languageEnglish (US)
Pages (from-to)189-200
Number of pages12
JournalCurrent treatment options in oncology
Volume13
Issue number2
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

Keywords

  • ARN-509
  • Abiraterone
  • Androgen receptor antagonists
  • CYP17 inhibitors
  • Galeterone
  • MDV3100
  • Metastatic castration-resistant prostate cancer
  • Orteronel

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