Angiocentric astrocytoma in a cat

Daniel R. Rissi, Brittany J. McHale, Anibal G. Armién

Research output: Contribution to journalArticlepeer-review


Gliomas are common primary central nervous system neoplasms of dogs and cats, but atypical glioma subtypes are rare. Herein we report an angiocentric astrocytoma in a 15-y-old spayed female domestic shorthaired cat that was euthanized after therapy-resistant seizures. Gross anatomic changes consisted of swelling of the rostral leptomeninges over the olfactory bulbs and rostral telencephalon. Histologically, polygonal-to-elongate atypical neoplastic cells were arranged along perivascular spaces within these areas. Neoplastic cells were positive for glial fibrillary acidic protein, S100 protein, and vimentin. Ultrastructurally, round-to-elongate neoplastic cells emitting long processes with aggregates of intermediary filaments expanded and occupied the spaces between the vascular basement membrane and the glia limitans; nuclei had marginal and central heterochromatin. Tight junctions connected the plasma membrane of neighboring cells. The cell morphology, immunohistochemistry, and ultrastructural findings were consistent with an astrocytoma; the exclusive perivascular arrangement of neoplastic cells with no parenchymal mass warranted the diagnosis of angiocentric astrocytoma.

Original languageEnglish (US)
Pages (from-to)576-580
Number of pages5
JournalJournal of Veterinary Diagnostic Investigation
Issue number4
StatePublished - Jul 1 2019


  • astrocytoma
  • cats
  • glioma
  • immunohistochemistry
  • neuropathology

PubMed: MeSH publication types

  • Case Reports
  • Journal Article

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