Abstract
Angiotensin II (A-II) has been found previously to increase mean arterial pressure (MAP) and enhance fluid absorption in the rat ileum in situ after intracerebroventricular (ICV) administration. In this investigation, the CNS-mediated proabsorptive actions of A-II and other products of the renin-angiotensin system, as well as nonhomologous peptides were further characterized in the urethane-anesthetized rat. At an ICV bolus dose of 1 μg, angiotensinogen, A-I, A-II and A-III produced significant elevations in MAP, but only A-II and A-III increased ileal absorption significantly above that of saline-treated rats. The ICV administration of other unrelated peptides did not mimic the actions of A-II or A-III. The results suggest that the pressor and ileal proabsorptive actions of angiotensins are mediated through different CNS mechanisms and that these peptides uniquely alter intestinal transport.
Original language | English (US) |
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Pages (from-to) | 245-247 |
Number of pages | 3 |
Journal | Peptides |
Volume | 10 |
Issue number | 1 |
DOIs | |
State | Published - 1989 |
Bibliographical note
Funding Information:This work was supported by U.S.P.H.S. grant No. DK-35260.
Keywords
- Absorption
- Angiotensin
- Blood pressure
- CNS
- Ileum
- Jejunum
- Renin
- Somatostatin
- TRH