Animal Models of Congenital Cytomegalovirus Transmission: Implications for Vaccine Development

Hunter K. Roark; Jennifer A. Jenks; Sallie R. Permar; Mark R. Schleiss

doi:10.1093/infdis/jiz484

Animal Models of Congenital Cytomegalovirus Transmission: Implications for Vaccine Development

Hunter K. Roark, Jennifer A. Jenks, Sallie R. Permar, Mark R. Schleiss

Pediatrics - Infectious Disease

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25 Scopus citations

Abstract

Although cytomegaloviruses (CMVs) are species-specific, the study of nonhuman CMVs in animal models can help to inform and direct research aimed at developing a human CMV (HCMV) vaccine. Because the driving force behind the development of HCMV vaccines is to prevent congenital infection, the animal model in question must be one in which vertical transmission of virus occurs to the fetus. Fortunately, two such animal models-the rhesus macaque CMV and guinea pig CMV-are characterized by congenital infection. Hence, each model can be evaluated in "proof-of-concept" studies of preconception vaccination aimed at blocking transplacental transmission. This review focuses on similarities and differences in the respective model systems, and it discusses key insights from each model germane to the study of HCMV vaccines.

Original language	English (US)
Pages (from-to)	S60-S73
Journal	The Journal of infectious diseases
Volume	221
Issue number	1
DOIs	https://doi.org/10.1093/infdis/jiz484
State	Published - Mar 5 2020

Keywords

Congenital cytomegalovirus
cytomegalovirus glycoproteins
cytomegalovirus vaccines
guinea pig cytomegalovirus
rhesus macaque cytomegalovirus

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Review

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title = "Animal Models of Congenital Cytomegalovirus Transmission: Implications for Vaccine Development",

abstract = "Although cytomegaloviruses (CMVs) are species-specific, the study of nonhuman CMVs in animal models can help to inform and direct research aimed at developing a human CMV (HCMV) vaccine. Because the driving force behind the development of HCMV vaccines is to prevent congenital infection, the animal model in question must be one in which vertical transmission of virus occurs to the fetus. Fortunately, two such animal models-the rhesus macaque CMV and guinea pig CMV-are characterized by congenital infection. Hence, each model can be evaluated in {"}proof-of-concept{"} studies of preconception vaccination aimed at blocking transplacental transmission. This review focuses on similarities and differences in the respective model systems, and it discusses key insights from each model germane to the study of HCMV vaccines.",

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AU - Schleiss, Mark R.

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N2 - Although cytomegaloviruses (CMVs) are species-specific, the study of nonhuman CMVs in animal models can help to inform and direct research aimed at developing a human CMV (HCMV) vaccine. Because the driving force behind the development of HCMV vaccines is to prevent congenital infection, the animal model in question must be one in which vertical transmission of virus occurs to the fetus. Fortunately, two such animal models-the rhesus macaque CMV and guinea pig CMV-are characterized by congenital infection. Hence, each model can be evaluated in "proof-of-concept" studies of preconception vaccination aimed at blocking transplacental transmission. This review focuses on similarities and differences in the respective model systems, and it discusses key insights from each model germane to the study of HCMV vaccines.

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Animal Models of Congenital Cytomegalovirus Transmission: Implications for Vaccine Development

Abstract

Keywords

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UN SDGs

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