Antagonism by chlornaltrexamine of some effects of Δ9-tetrahydrocannabinol in rats

F. C. Tulunay; I. H. Ayhan; P. S. Portoghese; A. E. Takemori

doi:10.1016/0014-2999(81)90217-X

Antagonism by chlornaltrexamine of some effects of Δ⁹-tetrahydrocannabinol in rats

F. C. Tulunay, I. H. Ayhan, P. S. Portoghese, A. E. Takemori

Medicinal Chemistry

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Abstract

Chlornaltrexamine (β-CNA) a selective, long-acting irreversible opiate antagonist inhibited the analgesia, hypothermia, hypothermic tolerance and physical dependence produced by Δ⁹-tetrahydrocannabinol (THC) in rats. The results suggest that there are some common features between cannabis and opiates and some actions of THC may be mediated by opioid related mechanisms in the central nervous system.

Original language	English (US)
Pages (from-to)	219-224
Number of pages	6
Journal	European Journal of Pharmacology
Volume	70
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(81)90217-X
State	Published - Mar 12 1981

Keywords

Analgesia
Chlornaltrexamine
Dependence
Hypothermia
Morphine
THC
Tolerance
Δ-Tetrahydrocannabinol
β-CNA

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10.1016/0014-2999(81)90217-X

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title = "Antagonism by chlornaltrexamine of some effects of Δ9-tetrahydrocannabinol in rats",

abstract = "Chlornaltrexamine (β-CNA) a selective, long-acting irreversible opiate antagonist inhibited the analgesia, hypothermia, hypothermic tolerance and physical dependence produced by Δ9-tetrahydrocannabinol (THC) in rats. The results suggest that there are some common features between cannabis and opiates and some actions of THC may be mediated by opioid related mechanisms in the central nervous system.",

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AU - Takemori, A. E.

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