Antagonism by chlornaltrexamine of some effects of Δ9-tetrahydrocannabinol in rats

F. C. Tulunay, I. H. Ayhan, P. S. Portoghese, A. E. Takemori

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47 Scopus citations

Abstract

Chlornaltrexamine (β-CNA) a selective, long-acting irreversible opiate antagonist inhibited the analgesia, hypothermia, hypothermic tolerance and physical dependence produced by Δ9-tetrahydrocannabinol (THC) in rats. The results suggest that there are some common features between cannabis and opiates and some actions of THC may be mediated by opioid related mechanisms in the central nervous system.

Original languageEnglish (US)
Pages (from-to)219-224
Number of pages6
JournalEuropean Journal of Pharmacology
Volume70
Issue number2
DOIs
StatePublished - Mar 12 1981

Keywords

  • Analgesia
  • Chlornaltrexamine
  • Dependence
  • Hypothermia
  • Morphine
  • THC
  • Tolerance
  • Δ-Tetrahydrocannabinol
  • β-CNA

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