TY - JOUR
T1 - Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds
T2 - Studies using human acute lymphoblastic leukemia cells and the zebrafish model
AU - Benyumov, Alexey O.
AU - Venkatachalam, Taracad K.
AU - Grigoriants, Olga O.
AU - Vassilev, Alexei O.
AU - Tibbles, Heather E.
AU - Downs, Suzanne
AU - Dumez, Darin
AU - Uckun, Fatih M.
PY - 2005
Y1 - 2005
N2 - The anti-proliferative effects of a novel bromomethoxylated arylphosphate derivative of zidovudine (compound DDE46, CAS 213982-96-8) were first examined in a zebra fish embryo model. DDE46 blocked the cell division at the 2-cell stage of the embryonic development followed by total cell fusion. DDE46 also inhibited the proliferation of the leukemic cell lines NALM-6 and MOLT-3. DDE46 enhanced the activity of the pro-apoptotic enzymes Caspase-3, Caspase-6, Caspase-8, and Caspase-9 leading to the apoptotic death of the leukemic cell line Jurkat. These results justify the further development of this agent as a new anti-leukemic drug candidate.
AB - The anti-proliferative effects of a novel bromomethoxylated arylphosphate derivative of zidovudine (compound DDE46, CAS 213982-96-8) were first examined in a zebra fish embryo model. DDE46 blocked the cell division at the 2-cell stage of the embryonic development followed by total cell fusion. DDE46 also inhibited the proliferation of the leukemic cell lines NALM-6 and MOLT-3. DDE46 enhanced the activity of the pro-apoptotic enzymes Caspase-3, Caspase-6, Caspase-8, and Caspase-9 leading to the apoptotic death of the leukemic cell line Jurkat. These results justify the further development of this agent as a new anti-leukemic drug candidate.
KW - CAS 213982-96-8
KW - DDE46, antileukemic activity, apoptosis, Zebrafish model
KW - Zidovudine, bromomethoxylated arylphosphate derivative
UR - http://www.scopus.com/inward/record.url?scp=14744277358&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=14744277358&partnerID=8YFLogxK
U2 - 10.1055/s-0031-1296832
DO - 10.1055/s-0031-1296832
M3 - Article
C2 - 15787279
AN - SCOPUS:14744277358
SN - 0004-4172
VL - 55
SP - 114
EP - 122
JO - Arzneimittel-Forschung/Drug Research
JF - Arzneimittel-Forschung/Drug Research
IS - 2
ER -
