TY - JOUR
T1 - Antibacterial synergy of glycerol monolaurate and aminoglycosides in Staphylococcus aureus biofilms
AU - Hess, Donavon J.
AU - Henry-Stanley, Michelle J.
AU - Wells, Carol L.
N1 - Publisher Copyright:
Copyright © 2014, American Society for Microbiology. All Rights Reserved.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Glycerol monolaurate (GML) is a natural surfactant with antimicrobial properties. At ∼0.3 mM, both GML and its component lauric acid were bactericidal for antibiotic-resistant Staphylococcus aureus biofilms. With the use of MICs of antibiotics obtained from planktonic cells, GML and lauric acid acted synergistically with gentamicin and streptomycin, but not ampicillin or vancomycin, to eliminate detectable viable biofilm bacteria. Images of GML-treated biofilms suggested that GML may facilitate antibiotic interaction with matrix-embedded bacteria.
AB - Glycerol monolaurate (GML) is a natural surfactant with antimicrobial properties. At ∼0.3 mM, both GML and its component lauric acid were bactericidal for antibiotic-resistant Staphylococcus aureus biofilms. With the use of MICs of antibiotics obtained from planktonic cells, GML and lauric acid acted synergistically with gentamicin and streptomycin, but not ampicillin or vancomycin, to eliminate detectable viable biofilm bacteria. Images of GML-treated biofilms suggested that GML may facilitate antibiotic interaction with matrix-embedded bacteria.
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U2 - 10.1128/AAC.03672-14
DO - 10.1128/AAC.03672-14
M3 - Article
C2 - 25182634
AN - SCOPUS:84908397835
SN - 0066-4804
VL - 58
SP - 6970
EP - 6973
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 11
ER -