Antibiotic resistance patterns in invasive group B streptococcal isolates

Ruth Lynfield; Mei L. Castor; Cynthia G. Whitney; Kathryn Como-Sabetti; Richard R. Facklam; Patricia Ferrieri; Joanne M. Bartkus; Billie A. Juni; Paul R. Cieslak; Monica M. Farley; Nellie B. Dumas; Stephanie J. Schrag

doi:10.1155/2008/727505

Antibiotic resistance patterns in invasive group B streptococcal isolates

Ruth Lynfield, Mei L. Castor, Cynthia G. Whitney, Kathryn Como-Sabetti, Richard R. Facklam, Patricia Ferrieri, Joanne M. Bartkus, Billie A. Juni, Paul R. Cieslak, Monica M. Farley, Nellie B. Dumas, Stephanie J. Schrag

Laboratory Medicine and Pathology

Research output: Contribution to journal › Review article › peer-review

102 Scopus citations

Abstract

Antibiotics are used for both group B streptococcal (GBS) prevention and treatment. Active population-based surveillance for invasive GBS disease was conducted in four states during 1996-2003. Of 3813 case-isolates, 91.0% (3471) were serotyped, 77.1% (2937) had susceptibility testing, and 46.6% (3471) had both. All were sensitive to penicillin, ampicillin, cefazolin, cefotaxime, and vancomycin. Clindamycin and erythromycin resistance was 12.7% and 25.6%, respectively, and associated with serotype V (P <.001). Clindamycin resistance increased from 10.5% to 15.0% (X 2 for trend 12.70; P <.001); inducible clindamycin resistance was associated with the erm genotype. Erythromycin resistance increased from 15.8% to 32.8% (X 2 for trend 55.46; P <.001). While GBS remains susceptible to beta-lactams, resistance to alternative agents such as erythromycin and clindamycin is an increasing concern.

Original language	English (US)
Article number	727505
Journal	Infectious Diseases in Obstetrics and Gynecology
Volume	2008
DOIs	https://doi.org/10.1155/2008/727505
State	Published - 2008

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Lynfield, R., Castor, M. L., Whitney, C. G., Como-Sabetti, K., Facklam, R. R., Ferrieri, P., Bartkus, J. M., Juni, B. A., Cieslak, P. R., Farley, M. M., Dumas, N. B., & Schrag, S. J. (2008). Antibiotic resistance patterns in invasive group B streptococcal isolates. Infectious Diseases in Obstetrics and Gynecology, 2008, Article 727505. https://doi.org/10.1155/2008/727505

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abstract = "Antibiotics are used for both group B streptococcal (GBS) prevention and treatment. Active population-based surveillance for invasive GBS disease was conducted in four states during 1996-2003. Of 3813 case-isolates, 91.0% (3471) were serotyped, 77.1% (2937) had susceptibility testing, and 46.6% (3471) had both. All were sensitive to penicillin, ampicillin, cefazolin, cefotaxime, and vancomycin. Clindamycin and erythromycin resistance was 12.7% and 25.6%, respectively, and associated with serotype V (P <.001). Clindamycin resistance increased from 10.5% to 15.0% (X 2 for trend 12.70; P <.001); inducible clindamycin resistance was associated with the erm genotype. Erythromycin resistance increased from 15.8% to 32.8% (X 2 for trend 55.46; P <.001). While GBS remains susceptible to beta-lactams, resistance to alternative agents such as erythromycin and clindamycin is an increasing concern.",

author = "Ruth Lynfield and Castor, {Mei L.} and Whitney, {Cynthia G.} and Kathryn Como-Sabetti and Facklam, {Richard R.} and Patricia Ferrieri and Bartkus, {Joanne M.} and Juni, {Billie A.} and Cieslak, {Paul R.} and Farley, {Monica M.} and Dumas, {Nellie B.} and Schrag, {Stephanie J.}",

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AU - Como-Sabetti, Kathryn

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AU - Ferrieri, Patricia

AU - Bartkus, Joanne M.

AU - Juni, Billie A.

AU - Cieslak, Paul R.

AU - Farley, Monica M.

AU - Dumas, Nellie B.

AU - Schrag, Stephanie J.

PY - 2008

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N2 - Antibiotics are used for both group B streptococcal (GBS) prevention and treatment. Active population-based surveillance for invasive GBS disease was conducted in four states during 1996-2003. Of 3813 case-isolates, 91.0% (3471) were serotyped, 77.1% (2937) had susceptibility testing, and 46.6% (3471) had both. All were sensitive to penicillin, ampicillin, cefazolin, cefotaxime, and vancomycin. Clindamycin and erythromycin resistance was 12.7% and 25.6%, respectively, and associated with serotype V (P <.001). Clindamycin resistance increased from 10.5% to 15.0% (X 2 for trend 12.70; P <.001); inducible clindamycin resistance was associated with the erm genotype. Erythromycin resistance increased from 15.8% to 32.8% (X 2 for trend 55.46; P <.001). While GBS remains susceptible to beta-lactams, resistance to alternative agents such as erythromycin and clindamycin is an increasing concern.

AB - Antibiotics are used for both group B streptococcal (GBS) prevention and treatment. Active population-based surveillance for invasive GBS disease was conducted in four states during 1996-2003. Of 3813 case-isolates, 91.0% (3471) were serotyped, 77.1% (2937) had susceptibility testing, and 46.6% (3471) had both. All were sensitive to penicillin, ampicillin, cefazolin, cefotaxime, and vancomycin. Clindamycin and erythromycin resistance was 12.7% and 25.6%, respectively, and associated with serotype V (P <.001). Clindamycin resistance increased from 10.5% to 15.0% (X 2 for trend 12.70; P <.001); inducible clindamycin resistance was associated with the erm genotype. Erythromycin resistance increased from 15.8% to 32.8% (X 2 for trend 55.46; P <.001). While GBS remains susceptible to beta-lactams, resistance to alternative agents such as erythromycin and clindamycin is an increasing concern.

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Antibiotic resistance patterns in invasive group B streptococcal isolates

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