Antibodies to GM1 and GD1b in patients with motor neuron disease without plasma cell dyscrasia

Michael E. Shy, Vance A. Evans, Fred D. Lublin, Robert L. Knobler, Terry Heiman‐Patterson, Albert J. Tahmoush, Gareth J Parry, Paul Schick, Theodora G. Deryk

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Fiftynine percent of 49 patients with motor neuron disease and 25% of 91 control subjects had IgM antibodies to ganglioside GM1 but usually not to GD1b at titers less than 1:80. This suggests that antibodies to GM1 may be part of the normal human antibody repertoire. However, given the higher incidence of antibodies to GM1 in patients with motor neuron disease, there may be specific epitopes important in antiganglioside antibodies associated with motor neuron disease.

Original languageEnglish (US)
Pages (from-to)511-513
Number of pages3
JournalAnnals of Neurology
Volume25
Issue number5
DOIs
StatePublished - May 1989

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