Antibody Response in the Rat II. Microclasmatosis, a Possible Mode of Antibody Release

Seong S. Han; Ihn H. Han; Arthur G. Johnson

doi:10.3181/00379727-121-30886

Antibody Response in the Rat II. Microclasmatosis, a Possible Mode of Antibody Release

Seong S. Han, Ihn H. Han, Arthur G. Johnson

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Electron microscopic observations were made of cells in spleens taken from Sprague-Dawley rats during the primary antibody response to bovine gamma globulin. Many of the resulting plasma cells were found to produce a series of vesicles by membrane invaginations which surrounded small pieces of the rough-surfaced endoplasmic reticulum (RER). By coalescence of these vesicles, chunks of cytoplasm containing the RER appeared to be liberated from the plasmacytic cells. The process, microclasmatosis, was postulated to represent one physiological way of release and transport of formed antibody globulins.

Original language	English (US)
Pages (from-to)	782-785
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	121
Issue number	3
DOIs	https://doi.org/10.3181/00379727-121-30886
State	Published - Mar 1966
Externally published	Yes

Bibliographical note

Funding Information:
This study was supported by USPHS Grant E 1524 and Am. Cancer Soc. Grant IN 40 D. 3 1966 121 3 782 785

Access

10.3181/00379727-121-30886

OpenUrl availability

Full text

Cite this

@article{bfacc50b71b2446dabef1d1862ab0558,

title = "Antibody Response in the Rat II. Microclasmatosis, a Possible Mode of Antibody Release",

abstract = "Electron microscopic observations were made of cells in spleens taken from Sprague-Dawley rats during the primary antibody response to bovine gamma globulin. Many of the resulting plasma cells were found to produce a series of vesicles by membrane invaginations which surrounded small pieces of the rough-surfaced endoplasmic reticulum (RER). By coalescence of these vesicles, chunks of cytoplasm containing the RER appeared to be liberated from the plasmacytic cells. The process, microclasmatosis, was postulated to represent one physiological way of release and transport of formed antibody globulins.",

author = "Han, {Seong S.} and Han, {Ihn H.} and Johnson, {Arthur G.}",

note = "Funding Information: This study was supported by USPHS Grant E 1524 and Am. Cancer Soc. Grant IN 40 D. 3 1966 121 3 782 785 ",

year = "1966",

month = mar,

doi = "10.3181/00379727-121-30886",

language = "English (US)",

volume = "121",

pages = "782--785",

journal = "Proceedings of the Society for Experimental Biology and Medicine",

issn = "0037-9727",

publisher = "Sage Publications",

number = "3",

}

TY - JOUR

T1 - Antibody Response in the Rat II. Microclasmatosis, a Possible Mode of Antibody Release

AU - Han, Seong S.

AU - Han, Ihn H.

AU - Johnson, Arthur G.

N1 - Funding Information: This study was supported by USPHS Grant E 1524 and Am. Cancer Soc. Grant IN 40 D. 3 1966 121 3 782 785

PY - 1966/3

Y1 - 1966/3

N2 - Electron microscopic observations were made of cells in spleens taken from Sprague-Dawley rats during the primary antibody response to bovine gamma globulin. Many of the resulting plasma cells were found to produce a series of vesicles by membrane invaginations which surrounded small pieces of the rough-surfaced endoplasmic reticulum (RER). By coalescence of these vesicles, chunks of cytoplasm containing the RER appeared to be liberated from the plasmacytic cells. The process, microclasmatosis, was postulated to represent one physiological way of release and transport of formed antibody globulins.

AB - Electron microscopic observations were made of cells in spleens taken from Sprague-Dawley rats during the primary antibody response to bovine gamma globulin. Many of the resulting plasma cells were found to produce a series of vesicles by membrane invaginations which surrounded small pieces of the rough-surfaced endoplasmic reticulum (RER). By coalescence of these vesicles, chunks of cytoplasm containing the RER appeared to be liberated from the plasmacytic cells. The process, microclasmatosis, was postulated to represent one physiological way of release and transport of formed antibody globulins.

UR - http://www.scopus.com/inward/record.url?scp=0013890124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0013890124&partnerID=8YFLogxK

U2 - 10.3181/00379727-121-30886

DO - 10.3181/00379727-121-30886

M3 - Article

C2 - 4160705

AN - SCOPUS:0013890124

SN - 0037-9727

VL - 121

SP - 782

EP - 785

JO - Proceedings of the Society for Experimental Biology and Medicine

JF - Proceedings of the Society for Experimental Biology and Medicine

IS - 3

ER -

Antibody Response in the Rat II. Microclasmatosis, a Possible Mode of Antibody Release

Abstract

Bibliographical note

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this